Regulated Degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage
Chaperone-mediated autophagy (CMA) is activate in response to cellular stressors to prevent cellular proteotoxicity through selective degradation of altered proteins in lysosomes. Reduced CMA activity contributes to the decrease in proteome quality in disease and aging. Here, we report that CMA is a...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400843/ |