A Review of Collagen Cross-Linking in Cornea and Sclera

Riboflavin/UVA cross-linking is a technique introduced in the past decades for the treatment of keratoconus, keratectasia, and infectious keratitis. Its efficacy and safety have been investigated with clinical and laboratory studies since its first clinical application by Wollensak for the treatment...

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Main Authors:	Zhang, Xiao, Tao, Xiang-chen, Zhang, Jian, Li, Zhi-wei, Xu, Yan-yun, Wang, Yu-meng, Zhang, Chun-xiao, Mu, Guo-ying
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398937/

id	pubmed-4398937
recordtype	oai_dc
spelling	pubmed-43989372015-04-28 A Review of Collagen Cross-Linking in Cornea and Sclera Zhang, Xiao Tao, Xiang-chen Zhang, Jian Li, Zhi-wei Xu, Yan-yun Wang, Yu-meng Zhang, Chun-xiao Mu, Guo-ying Review Article Riboflavin/UVA cross-linking is a technique introduced in the past decades for the treatment of keratoconus, keratectasia, and infectious keratitis. Its efficacy and safety have been investigated with clinical and laboratory studies since its first clinical application by Wollensak for the treatment of keratoconus. Although its complications are encountered during clinical practice, such as infection inducing risk, minimal invasion merits a further investigation on its future application in clinical practice. Recently, collagen cross-linking in sclera shows a promising prospect. In present study, we summarized the representative studies describing the clinical and laboratory application of collagen cross-linking published in past decades and provided our opinion on the positive and negative results of cross-linking in the treatment of ophthalmic disorders. Hindawi Publishing Corporation 2015 2015-04-02 /pmc/articles/PMC4398937/ /pubmed/25922758 http://dx.doi.org/10.1155/2015/289467 Text en Copyright © 2015 Xiao Zhang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Zhang, Xiao Tao, Xiang-chen Zhang, Jian Li, Zhi-wei Xu, Yan-yun Wang, Yu-meng Zhang, Chun-xiao Mu, Guo-ying
spellingShingle	Zhang, Xiao Tao, Xiang-chen Zhang, Jian Li, Zhi-wei Xu, Yan-yun Wang, Yu-meng Zhang, Chun-xiao Mu, Guo-ying A Review of Collagen Cross-Linking in Cornea and Sclera
author_facet	Zhang, Xiao Tao, Xiang-chen Zhang, Jian Li, Zhi-wei Xu, Yan-yun Wang, Yu-meng Zhang, Chun-xiao Mu, Guo-ying
author_sort	Zhang, Xiao
title	A Review of Collagen Cross-Linking in Cornea and Sclera
title_short	A Review of Collagen Cross-Linking in Cornea and Sclera
title_full	A Review of Collagen Cross-Linking in Cornea and Sclera
title_fullStr	A Review of Collagen Cross-Linking in Cornea and Sclera
title_full_unstemmed	A Review of Collagen Cross-Linking in Cornea and Sclera
title_sort	review of collagen cross-linking in cornea and sclera
description	Riboflavin/UVA cross-linking is a technique introduced in the past decades for the treatment of keratoconus, keratectasia, and infectious keratitis. Its efficacy and safety have been investigated with clinical and laboratory studies since its first clinical application by Wollensak for the treatment of keratoconus. Although its complications are encountered during clinical practice, such as infection inducing risk, minimal invasion merits a further investigation on its future application in clinical practice. Recently, collagen cross-linking in sclera shows a promising prospect. In present study, we summarized the representative studies describing the clinical and laboratory application of collagen cross-linking published in past decades and provided our opinion on the positive and negative results of cross-linking in the treatment of ophthalmic disorders.
publisher	Hindawi Publishing Corporation
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398937/
_version_	1613212237779959808

A Review of Collagen Cross-Linking in Cornea and Sclera

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