Neofunctionalization of the Sec1 α1,2fucosyltransferase Paralogue in Leporids Contributes to Glycan Polymorphism and Resistance to Rabbit Hemorrhagic Disease Virus

Neofunctionalization of the Sec1 α1,2fucosyltransferase Paralogue in Leporids Contributes to Glycan Polymorphism and Resistance to Rabbit Hemorrhagic Disease Virus

RHDV (rabbit hemorrhagic disease virus), a virulent calicivirus, causes high mortalities in European rabbit populations (Oryctolagus cuniculus). It uses α1,2fucosylated glycans, histo-blood group antigens (HBGAs), as attachment factors, with their absence or low expression generating resistance to t...

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Bibliographic Details
Main Authors: Nyström, Kristina, Abrantes, Joana, Lopes, Ana Margarida, Le Moullac-Vaidye, Béatrice, Marchandeau, Stéphane, Rocher, Jézabel, Ruvoën-Clouet, Nathalie, Esteves, Pedro J., Le Pendu, Jacques
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398370/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398370/

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