Insulin Reverses D-Glucose–Increased Nitric Oxide and Reactive Oxygen Species Generation in Human Umbilical Vein Endothelial Cells

Insulin Reverses D-Glucose–Increased Nitric Oxide and Reactive Oxygen Species Generation in Human Umbilical Vein Endothelial Cells

Vascular tone is controlled by the L-arginine/nitric oxide (NO) pathway, and NO bioavailability is strongly affected by hyperglycaemia-induced oxidative stress. Insulin leads to high expression and activity of human cationic amino acid transporter 1 (hCAT-1), NO synthesis and vasodilation; thus, a p...

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Bibliographic Details
Main Authors: González, Marcelo, Rojas, Susana, Avila, Pía, Cabrera, Lissette, Villalobos, Roberto, Palma, Carlos, Aguayo, Claudio, Peña, Eduardo, Gallardo, Victoria, Guzmán-Gutiérrez, Enrique, Sáez, Tamara, Salsoso, Rocío, Sanhueza, Carlos, Pardo, Fabián, Leiva, Andrea, Sobrevia, Luis
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397070/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397070/

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