Integrative Analysis of CRISPR/Cas9 Target Sites in the Human HBB Gene

Recently, the clustered regularly interspaced short palindromic repeats (CRISPR) system has emerged as a powerful customizable artificial nuclease to facilitate precise genetic correction for tissue regeneration and isogenic disease modeling. However, previous studies reported substantial off-target...

Full description

Bibliographic Details
Main Authors: Luo, Yumei, Zhu, Detu, Zhang, Zhizhuo, Chen, Yaoyong, Sun, Xiaofang
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396065/