Hepatitis C Virus RNA Replication Depends on Specific Cis- and Trans-Acting Activities of Viral Nonstructural Proteins

Hepatitis C Virus RNA Replication Depends on Specific Cis- and Trans-Acting Activities of Viral Nonstructural Proteins

Many positive-strand RNA viruses encode genes that can function in trans, whereas other genes are required in cis for genome replication. The mechanisms underlying trans- and cis-preferences are not fully understood. Here, we evaluate this concept for hepatitis C virus (HCV), an important cause of c...

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Bibliographic Details
Main Authors: Kazakov, Teymur, Yang, Feng, Ramanathan, Harish N., Kohlway, Andrew, Diamond, Michael S., Lindenbach, Brett D.
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395149/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395149/

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