Tanshinone IIA attenuates bleomycin-induced pulmonary fibrosis in rats
Idiopathic pulmonary fibrosis is a chronic and progressive fibrotic lung disorder with unknown etiology and a high mortality rate. Tanshinone IIA (Tan IIA) is a lipophilic diterpene extracted from the Chinese herb Salvia miltiorrhiza Bunge with diverse biological functions. The present study was con...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
D.A. Spandidos
2015
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394983/ |
| id |
pubmed-4394983 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-43949832015-04-17 Tanshinone IIA attenuates bleomycin-induced pulmonary fibrosis in rats HE, HUANYU TANG, HAIYING GAO, LILI WU, YUN FENG, ZHIQIANG LIN, HONGLI WU, TAIHUA Articles Idiopathic pulmonary fibrosis is a chronic and progressive fibrotic lung disorder with unknown etiology and a high mortality rate. Tanshinone IIA (Tan IIA) is a lipophilic diterpene extracted from the Chinese herb Salvia miltiorrhiza Bunge with diverse biological functions. The present study was conducted to evaluate the effects of Tan IIA on bleomycin (BLM)-induced pulmonary fibrosis in rats. Rats received an intraperitoneal injection of Tan IIA and normal rats were used as controls. Severe pulmonary edema, inflammation and fibrosis were observed in the BLM-treated rats and the counts of total cells, neutrophils and lymphocytes were significantly increased in the bronchoalveolar lavage fluids of those rats. These pathological changes were markedly attenuated by subsequent treatment with Tan IIA. In addition, BLM-induced increased expression of tumor necrosis factor-α, interleukin (IL)-1β, IL-6, cyclooxygenase-2, prostaglandin E2, malondialdehyde, inducible nitric oxide synthase and nitric oxide in rats, which was also suppressed by Tan IIA injection. The present findings suggest therapeutic potential of Tan IIA for pulmonary fibrosis. D.A. Spandidos 2015-06 2015-02-11 /pmc/articles/PMC4394983/ /pubmed/25672255 http://dx.doi.org/10.3892/mmr.2015.3333 Text en Copyright © 2015, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
HE, HUANYU TANG, HAIYING GAO, LILI WU, YUN FENG, ZHIQIANG LIN, HONGLI WU, TAIHUA |
| spellingShingle |
HE, HUANYU TANG, HAIYING GAO, LILI WU, YUN FENG, ZHIQIANG LIN, HONGLI WU, TAIHUA Tanshinone IIA attenuates bleomycin-induced pulmonary fibrosis in rats |
| author_facet |
HE, HUANYU TANG, HAIYING GAO, LILI WU, YUN FENG, ZHIQIANG LIN, HONGLI WU, TAIHUA |
| author_sort |
HE, HUANYU |
| title |
Tanshinone IIA attenuates bleomycin-induced pulmonary fibrosis in rats |
| title_short |
Tanshinone IIA attenuates bleomycin-induced pulmonary fibrosis in rats |
| title_full |
Tanshinone IIA attenuates bleomycin-induced pulmonary fibrosis in rats |
| title_fullStr |
Tanshinone IIA attenuates bleomycin-induced pulmonary fibrosis in rats |
| title_full_unstemmed |
Tanshinone IIA attenuates bleomycin-induced pulmonary fibrosis in rats |
| title_sort |
tanshinone iia attenuates bleomycin-induced pulmonary fibrosis in rats |
| description |
Idiopathic pulmonary fibrosis is a chronic and progressive fibrotic lung disorder with unknown etiology and a high mortality rate. Tanshinone IIA (Tan IIA) is a lipophilic diterpene extracted from the Chinese herb Salvia miltiorrhiza Bunge with diverse biological functions. The present study was conducted to evaluate the effects of Tan IIA on bleomycin (BLM)-induced pulmonary fibrosis in rats. Rats received an intraperitoneal injection of Tan IIA and normal rats were used as controls. Severe pulmonary edema, inflammation and fibrosis were observed in the BLM-treated rats and the counts of total cells, neutrophils and lymphocytes were significantly increased in the bronchoalveolar lavage fluids of those rats. These pathological changes were markedly attenuated by subsequent treatment with Tan IIA. In addition, BLM-induced increased expression of tumor necrosis factor-α, interleukin (IL)-1β, IL-6, cyclooxygenase-2, prostaglandin E2, malondialdehyde, inducible nitric oxide synthase and nitric oxide in rats, which was also suppressed by Tan IIA injection. The present findings suggest therapeutic potential of Tan IIA for pulmonary fibrosis. |
| publisher |
D.A. Spandidos |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394983/ |
| _version_ |
1613210956649725952 |