Point application with Angong Niuhuang sticker protects hippocampal and cortical neurons in rats with cerebral ischemia

Angong Niuhuang pill, a Chinese materia medica preparation, can improve neurological functions after acute ischemic stroke. Because of its inconvenient application and toxic components (Cinnabaris and Realgar), we used transdermal enhancers to deliver Angong Niuhuang pill by modern technology, which...

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Main Authors:	Zhang, Dong-shu, Liu, Yuan-liang, Zhu, Dao-qi, Huang, Xiao-jing, Luo, Chao-hua
Format:	Online
Language:	English
Published:	Medknow Publications & Media Pvt Ltd 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392678/

id	pubmed-4392678
recordtype	oai_dc
spelling	pubmed-43926782015-04-16 Point application with Angong Niuhuang sticker protects hippocampal and cortical neurons in rats with cerebral ischemia Zhang, Dong-shu Liu, Yuan-liang Zhu, Dao-qi Huang, Xiao-jing Luo, Chao-hua Research Article Angong Niuhuang pill, a Chinese materia medica preparation, can improve neurological functions after acute ischemic stroke. Because of its inconvenient application and toxic components (Cinnabaris and Realgar), we used transdermal enhancers to deliver Angong Niuhuang pill by modern technology, which expanded the safe dose range and clinical indications. In this study, Angong Niuhuang stickers administered at different point application doses (1.35, 2.7, and 5.4 g/kg) were administered to the Dazhui (DU14), Qihai (RN6) and Mingmen (DU4) of rats with chronic cerebral ischemia, for 4 weeks. The Morris water maze was used to determine the learning and memory ability of rats. Hematoxylin-eosin staining and Nissl staining were used to observe neuronal damage of the cortex and hippocampal CA1 region in rats with chronic cerebral ischemia. The middle- and high-dose point application of Angong Niuhuang stickers attenuated neuronal damage in the cortex and hippocampal CA1 region, and improved the memory of rats with chronic cerebral ischemia with an efficacy similar to interventions by electroacupuncture at Dazhui (DU14), Qihai (RN6) and Mingmen (DU4). Our experimental findings indicate that point application with Angong Niuhuang stickers can improve cognitive function after chronic cerebral ischemia in rats and is neuroprotective with an equivalent efficacy to acupuncture. Medknow Publications & Media Pvt Ltd 2015-02 /pmc/articles/PMC4392678/ /pubmed/25883629 http://dx.doi.org/10.4103/1673-5374.152384 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Zhang, Dong-shu Liu, Yuan-liang Zhu, Dao-qi Huang, Xiao-jing Luo, Chao-hua
spellingShingle	Zhang, Dong-shu Liu, Yuan-liang Zhu, Dao-qi Huang, Xiao-jing Luo, Chao-hua Point application with Angong Niuhuang sticker protects hippocampal and cortical neurons in rats with cerebral ischemia
author_facet	Zhang, Dong-shu Liu, Yuan-liang Zhu, Dao-qi Huang, Xiao-jing Luo, Chao-hua
author_sort	Zhang, Dong-shu
title	Point application with Angong Niuhuang sticker protects hippocampal and cortical neurons in rats with cerebral ischemia
title_short	Point application with Angong Niuhuang sticker protects hippocampal and cortical neurons in rats with cerebral ischemia
title_full	Point application with Angong Niuhuang sticker protects hippocampal and cortical neurons in rats with cerebral ischemia
title_fullStr	Point application with Angong Niuhuang sticker protects hippocampal and cortical neurons in rats with cerebral ischemia
title_full_unstemmed	Point application with Angong Niuhuang sticker protects hippocampal and cortical neurons in rats with cerebral ischemia
title_sort	point application with angong niuhuang sticker protects hippocampal and cortical neurons in rats with cerebral ischemia
description	Angong Niuhuang pill, a Chinese materia medica preparation, can improve neurological functions after acute ischemic stroke. Because of its inconvenient application and toxic components (Cinnabaris and Realgar), we used transdermal enhancers to deliver Angong Niuhuang pill by modern technology, which expanded the safe dose range and clinical indications. In this study, Angong Niuhuang stickers administered at different point application doses (1.35, 2.7, and 5.4 g/kg) were administered to the Dazhui (DU14), Qihai (RN6) and Mingmen (DU4) of rats with chronic cerebral ischemia, for 4 weeks. The Morris water maze was used to determine the learning and memory ability of rats. Hematoxylin-eosin staining and Nissl staining were used to observe neuronal damage of the cortex and hippocampal CA1 region in rats with chronic cerebral ischemia. The middle- and high-dose point application of Angong Niuhuang stickers attenuated neuronal damage in the cortex and hippocampal CA1 region, and improved the memory of rats with chronic cerebral ischemia with an efficacy similar to interventions by electroacupuncture at Dazhui (DU14), Qihai (RN6) and Mingmen (DU4). Our experimental findings indicate that point application with Angong Niuhuang stickers can improve cognitive function after chronic cerebral ischemia in rats and is neuroprotective with an equivalent efficacy to acupuncture.
publisher	Medknow Publications & Media Pvt Ltd
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392678/
_version_	1613210142726160384

Point application with Angong Niuhuang sticker protects hippocampal and cortical neurons in rats with cerebral ischemia

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