Safety of Chinese Herbal Medicine for Chronic Obstructive Pulmonary Disease

Chinese herbal medicine (CHM) is increasingly used by patients with chronic obstructive pulmonary disease (COPD); however, there has been no systematic evaluation of its safety. This review examined the adverse events (AEs) reported in clinical studies of CHM for COPD. Five English databases (PubMed...

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Main Authors:	Coyle, Meaghan, Shergis, Johannah Linda, Liu, Shaonan, Wu, Lei, Zhang, Anthony Lin, Guo, Xinfeng, Lu, Chuanjian, Xue, Charlie Changli
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391162/

id	pubmed-4391162
recordtype	oai_dc
spelling	pubmed-43911622015-04-16 Safety of Chinese Herbal Medicine for Chronic Obstructive Pulmonary Disease Coyle, Meaghan Shergis, Johannah Linda Liu, Shaonan Wu, Lei Zhang, Anthony Lin Guo, Xinfeng Lu, Chuanjian Xue, Charlie Changli Review Article Chinese herbal medicine (CHM) is increasingly used by patients with chronic obstructive pulmonary disease (COPD); however, there has been no systematic evaluation of its safety. This review examined the adverse events (AEs) reported in clinical studies of CHM for COPD. Five English databases (PubMed, Embase, CINAHL, AMED, and CENTRAL) and four Chinese databases (CBM, CNKI, CQVIP, and Wanfang Data) were searched from inception to May 2013. Adverse event data, including nature, severity, author-assigned causality, management, and outcome, were extracted from included studies. Descriptive statistics were used for the rate of adverse events. Of the 152 included studies, AEs were reported in 47 studies. The rate of adverse events was slightly lower in the CHM groups compared with controls (84 events in 5,909 participants, 1.4% versus 102 events in 5,676 participants, 1.8%). The most frequently reported adverse event was nausea (28 cases in the CHM groups and 19 cases in the control groups), which was more common in studies where CHM was combined with pharmacotherapy to treat acute exacerbation of COPD. Other frequent adverse events were abdominal discomfort, dry mouth, and dizziness. Detailed information about the adverse events was scant. Overall, CHM appears to be well tolerated in people with COPD. Hindawi Publishing Corporation 2015 2015-03-26 /pmc/articles/PMC4391162/ /pubmed/25883670 http://dx.doi.org/10.1155/2015/380678 Text en Copyright © 2015 Meaghan Coyle et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Coyle, Meaghan Shergis, Johannah Linda Liu, Shaonan Wu, Lei Zhang, Anthony Lin Guo, Xinfeng Lu, Chuanjian Xue, Charlie Changli
spellingShingle	Coyle, Meaghan Shergis, Johannah Linda Liu, Shaonan Wu, Lei Zhang, Anthony Lin Guo, Xinfeng Lu, Chuanjian Xue, Charlie Changli Safety of Chinese Herbal Medicine for Chronic Obstructive Pulmonary Disease
author_facet	Coyle, Meaghan Shergis, Johannah Linda Liu, Shaonan Wu, Lei Zhang, Anthony Lin Guo, Xinfeng Lu, Chuanjian Xue, Charlie Changli
author_sort	Coyle, Meaghan
title	Safety of Chinese Herbal Medicine for Chronic Obstructive Pulmonary Disease
title_short	Safety of Chinese Herbal Medicine for Chronic Obstructive Pulmonary Disease
title_full	Safety of Chinese Herbal Medicine for Chronic Obstructive Pulmonary Disease
title_fullStr	Safety of Chinese Herbal Medicine for Chronic Obstructive Pulmonary Disease
title_full_unstemmed	Safety of Chinese Herbal Medicine for Chronic Obstructive Pulmonary Disease
title_sort	safety of chinese herbal medicine for chronic obstructive pulmonary disease
description	Chinese herbal medicine (CHM) is increasingly used by patients with chronic obstructive pulmonary disease (COPD); however, there has been no systematic evaluation of its safety. This review examined the adverse events (AEs) reported in clinical studies of CHM for COPD. Five English databases (PubMed, Embase, CINAHL, AMED, and CENTRAL) and four Chinese databases (CBM, CNKI, CQVIP, and Wanfang Data) were searched from inception to May 2013. Adverse event data, including nature, severity, author-assigned causality, management, and outcome, were extracted from included studies. Descriptive statistics were used for the rate of adverse events. Of the 152 included studies, AEs were reported in 47 studies. The rate of adverse events was slightly lower in the CHM groups compared with controls (84 events in 5,909 participants, 1.4% versus 102 events in 5,676 participants, 1.8%). The most frequently reported adverse event was nausea (28 cases in the CHM groups and 19 cases in the control groups), which was more common in studies where CHM was combined with pharmacotherapy to treat acute exacerbation of COPD. Other frequent adverse events were abdominal discomfort, dry mouth, and dizziness. Detailed information about the adverse events was scant. Overall, CHM appears to be well tolerated in people with COPD.
publisher	Hindawi Publishing Corporation
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391162/
_version_	1613209507149643776

Safety of Chinese Herbal Medicine for Chronic Obstructive Pulmonary Disease

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