Expanding the Species and Chemical Diversity of Penicillium Section Cinnamopurpurea

A set of isolates very similar to or potentially conspecific with an unidentified Penicillium isolate NRRL 735, was assembled using a BLAST search of ITS similarity among described (GenBank) and undescribed Penicillium isolates in our laboratories. DNA was amplified from six loci of the assembled is...

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Main Authors:	Peterson, Stephen W., Jurjević, Željko, Frisvad, Jens C.
Format:	Online
Language:	English
Published:	Public Library of Science 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390383/

id	pubmed-4390383
recordtype	oai_dc
spelling	pubmed-43903832015-04-21 Expanding the Species and Chemical Diversity of Penicillium Section Cinnamopurpurea Peterson, Stephen W. Jurjević, Željko Frisvad, Jens C. Research Article A set of isolates very similar to or potentially conspecific with an unidentified Penicillium isolate NRRL 735, was assembled using a BLAST search of ITS similarity among described (GenBank) and undescribed Penicillium isolates in our laboratories. DNA was amplified from six loci of the assembled isolates and sequenced. Two species in section Cinnamopurpurea are self-compatible sexual species, but the asexual species had polymorphic loci suggestive of sexual reproduction and variation in conidium size suggestive of ploidy level differences typical of heterothallism. Accordingly we use genealogical concordance analysis, a technique valid only in heterothallic organisms, for putatively asexual species. Seven new species were revealed in the analysis and are described here. Extrolite analysis showed that two of the new species, P. colei and P. monsserratidens produce the mycotoxin citreoviridin that has demonstrated pharmacological activity against human lung tumors. These isolates could provide leads in pharmaceutical research. Public Library of Science 2015-04-08 /pmc/articles/PMC4390383/ /pubmed/25853891 http://dx.doi.org/10.1371/journal.pone.0121987 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Peterson, Stephen W. Jurjević, Željko Frisvad, Jens C.
spellingShingle	Peterson, Stephen W. Jurjević, Željko Frisvad, Jens C. Expanding the Species and Chemical Diversity of Penicillium Section Cinnamopurpurea
author_facet	Peterson, Stephen W. Jurjević, Željko Frisvad, Jens C.
author_sort	Peterson, Stephen W.
title	Expanding the Species and Chemical Diversity of Penicillium Section Cinnamopurpurea
title_short	Expanding the Species and Chemical Diversity of Penicillium Section Cinnamopurpurea
title_full	Expanding the Species and Chemical Diversity of Penicillium Section Cinnamopurpurea
title_fullStr	Expanding the Species and Chemical Diversity of Penicillium Section Cinnamopurpurea
title_full_unstemmed	Expanding the Species and Chemical Diversity of Penicillium Section Cinnamopurpurea
title_sort	expanding the species and chemical diversity of penicillium section cinnamopurpurea
description	A set of isolates very similar to or potentially conspecific with an unidentified Penicillium isolate NRRL 735, was assembled using a BLAST search of ITS similarity among described (GenBank) and undescribed Penicillium isolates in our laboratories. DNA was amplified from six loci of the assembled isolates and sequenced. Two species in section Cinnamopurpurea are self-compatible sexual species, but the asexual species had polymorphic loci suggestive of sexual reproduction and variation in conidium size suggestive of ploidy level differences typical of heterothallism. Accordingly we use genealogical concordance analysis, a technique valid only in heterothallic organisms, for putatively asexual species. Seven new species were revealed in the analysis and are described here. Extrolite analysis showed that two of the new species, P. colei and P. monsserratidens produce the mycotoxin citreoviridin that has demonstrated pharmacological activity against human lung tumors. These isolates could provide leads in pharmaceutical research.
publisher	Public Library of Science
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390383/
_version_	1613209291911593984

Expanding the Species and Chemical Diversity of Penicillium Section Cinnamopurpurea

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