Peripheral Opioid Antagonist Enhances the Effect of Anti-Tumor Drug by Blocking a Cell Growth-Suppressive Pathway In Vivo

Peripheral Opioid Antagonist Enhances the Effect of Anti-Tumor Drug by Blocking a Cell Growth-Suppressive Pathway In Vivo

The dormancy of tumor cells is a major problem in chemotherapy, since it limits the therapeutic efficacy of anti-tumor drugs that only target dividing cells. One potential way to overcome chemo-resistance is to “wake up” these dormant cells. Here we show that the opioid antagonist methylnaltrexone (...

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Bibliographic Details
Main Authors: Suzuki, Masami, Chiwaki, Fumiko, Sawada, Yumi, Ashikawa, Maho, Aoyagi, Kazuhiko, Fujita, Takeshi, Yanagihara, Kazuyoshi, Komatsu, Masayuki, Narita, Minoru, Suzuki, Tsutomu, Nagase, Hiroshi, Kushima, Ryoji, Sakamoto, Hiromi, Fukagawa, Takeo, Katai, Hitoshi, Nakagama, Hitoshi, Yoshida, Teruhiko, Uezono, Yasuhito, Sasaki, Hiroki
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390307/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390307/

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