Endovascular renal denervation: a novel sympatholytic with relevance to chronic kidney disease

Endovascular renal denervation: a novel sympatholytic with relevance to chronic kidney disease

Endovascular renal denervation (sympathectomy) is a novel procedure developed for the treatment of resistant hypertension. Evidence suggests that it reduces both afferent and efferent sympathetic nerve activity, which may offer clinical benefit over and above any blood pressure-lowering effect. Stud...

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Main Authors: Hoye, Neil A., Baldi, James C., Putt, Tracey L., Schollum, John B., Wilkins, Gerard T., Walker, Robert J.
Format: Online
Language:English
Published: Oxford University Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389153/
id pubmed-4389153
recordtype oai_dc
spelling pubmed-43891532015-04-09 Endovascular renal denervation: a novel sympatholytic with relevance to chronic kidney disease Hoye, Neil A. Baldi, James C. Putt, Tracey L. Schollum, John B. Wilkins, Gerard T. Walker, Robert J. Original Contributions Endovascular renal denervation (sympathectomy) is a novel procedure developed for the treatment of resistant hypertension. Evidence suggests that it reduces both afferent and efferent sympathetic nerve activity, which may offer clinical benefit over and above any blood pressure-lowering effect. Studies have shown objective improvements in left ventricular mass, ventricular function, central arterial stiffness, central haemodynamics, baroreflex sensitivity and arrhythmia frequency. Benefits have also been seen in insulin resistance, microalbuminuria and glomerular filtration rate. In chronic kidney disease, elevated sympathetic activity has been causally linked to disease progression and cardiovascular sequelae. Effecting a marked reduction in sympathetic hyperactivity may herald a significant step in the management of this and other conditions. In this in-depth review, the pathophysiology and clinical significance of the sympatholytic effects of endovascular renal denervation are discussed. Oxford University Press 2014-02 2013-11-08 /pmc/articles/PMC4389153/ /pubmed/25859344 http://dx.doi.org/10.1093/ckj/sft130 Text en © The Author 2013. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For permissions, please email: journals.permissions@oup.com. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Hoye, Neil A.
Baldi, James C.
Putt, Tracey L.
Schollum, John B.
Wilkins, Gerard T.
Walker, Robert J.
spellingShingle Hoye, Neil A.
Baldi, James C.
Putt, Tracey L.
Schollum, John B.
Wilkins, Gerard T.
Walker, Robert J.
Endovascular renal denervation: a novel sympatholytic with relevance to chronic kidney disease
author_facet Hoye, Neil A.
Baldi, James C.
Putt, Tracey L.
Schollum, John B.
Wilkins, Gerard T.
Walker, Robert J.
author_sort Hoye, Neil A.
title Endovascular renal denervation: a novel sympatholytic with relevance to chronic kidney disease
title_short Endovascular renal denervation: a novel sympatholytic with relevance to chronic kidney disease
title_full Endovascular renal denervation: a novel sympatholytic with relevance to chronic kidney disease
title_fullStr Endovascular renal denervation: a novel sympatholytic with relevance to chronic kidney disease
title_full_unstemmed Endovascular renal denervation: a novel sympatholytic with relevance to chronic kidney disease
title_sort endovascular renal denervation: a novel sympatholytic with relevance to chronic kidney disease
description Endovascular renal denervation (sympathectomy) is a novel procedure developed for the treatment of resistant hypertension. Evidence suggests that it reduces both afferent and efferent sympathetic nerve activity, which may offer clinical benefit over and above any blood pressure-lowering effect. Studies have shown objective improvements in left ventricular mass, ventricular function, central arterial stiffness, central haemodynamics, baroreflex sensitivity and arrhythmia frequency. Benefits have also been seen in insulin resistance, microalbuminuria and glomerular filtration rate. In chronic kidney disease, elevated sympathetic activity has been causally linked to disease progression and cardiovascular sequelae. Effecting a marked reduction in sympathetic hyperactivity may herald a significant step in the management of this and other conditions. In this in-depth review, the pathophysiology and clinical significance of the sympatholytic effects of endovascular renal denervation are discussed.
publisher Oxford University Press
publishDate 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389153/
_version_ 1613208819955924992

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