Loss of the tumor suppressor Hace1 leads to ROS-dependent glutamine addiction

Loss of the tumor suppressor Hace1 leads to ROS-dependent glutamine addiction

Cellular transformation is associated with altered glutamine (Gln) metabolism. Tumor cells utilize Gln in the tricarboxylic acid (TCA) cycle to maintain sufficient pools of biosynthetic precursors to support rapid growth and proliferation. However, Gln metabolism also generates NADPH, and Gln-derive...

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Bibliographic Details
Main Authors: Cetinbas, Naniye, Daugaard, Mads, Mullen, Andrew, Hajee, Shamil, Rotblat, Barak, Lopez, Alejandra, Li, Amy, DeBerardinis, Ralph J, Sorensen, Poul H
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387113/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387113/

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