Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity

Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity

Activation of the PERK branch of the unfolded protein response (UPR) in response to protein misfolding within the endoplasmic reticulum (ER) results in the transient repression of protein synthesis, mediated by the phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2α). This...

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Bibliographic Details
Main Authors: Halliday, M, Radford, H, Sekine, Y, Moreno, J, Verity, N, le Quesne, J, Ortori, C A, Barrett, D A, Fromont, C, Fischer, P M, Harding, H P, Ron, D, Mallucci, G R
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385927/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385927/

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