Blockade of the JNK Signalling as a Rational Therapeutic Approach to Modulate the Early and Late Steps of the Inflammatory Cascade in Polymicrobial Sepsis

Blockade of the JNK Signalling as a Rational Therapeutic Approach to Modulate the Early and Late Steps of the Inflammatory Cascade in Polymicrobial Sepsis

Cecal ligation and puncture (CLP) is an experimental polymicrobial sepsis induced systemic inflammation that leads to acute organ failure. Aim of our study was to evaluate the effects of SP600125, a specific c-Jun NH2-terminal kinase (JNK) inhibitor, to modulate the early and late steps of the infla...

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Bibliographic Details
Main Authors: Pizzino, Gabriele, Bitto, Alessandra, Pallio, Giovanni, Irrera, Natasha, Galfo, Federica, Interdonato, Monica, Mecchio, Anna, De Luca, Filippo, Minutoli, Letteria, Squadrito, Francesco, Altavilla, Domenica
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385695/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385695/

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