MicroRNAs as Potential Biomarkers in Cancer: Opportunities and Challenges

MicroRNAs as Potential Biomarkers in Cancer: Opportunities and Challenges

MicroRNAs (miRNAs) are a group of small noncoding RNAs (ncRNAs) that posttranscriptionally regulate gene expression by targeting their corresponding messenger RNAs (mRNAs). Dysregulated miRNAs have been considered as a new type of ‘‘oncomiRs” or ‘‘tumor suppressors,” playing essential roles in cance...

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Main Authors: Lan, Huiyin, Lu, Haiqi, Wang, Xian, Jin, Hongchuan
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385606/
id pubmed-4385606
recordtype oai_dc
spelling pubmed-43856062015-04-13 MicroRNAs as Potential Biomarkers in Cancer: Opportunities and Challenges Lan, Huiyin Lu, Haiqi Wang, Xian Jin, Hongchuan Review Article MicroRNAs (miRNAs) are a group of small noncoding RNAs (ncRNAs) that posttranscriptionally regulate gene expression by targeting their corresponding messenger RNAs (mRNAs). Dysregulated miRNAs have been considered as a new type of ‘‘oncomiRs” or ‘‘tumor suppressors,” playing essential roles in cancer initiation and progression. Using genome-wide detection methods, ubiquitously aberrant expression profiles of miRNAs have been identified in a broad array of human cancers, showing great potential as novel diagnostic and prognostic biomarkers of cancer with high specificity and sensitivity. The detectable miRNAs in tissue, blood, and other body fluids with high stability provide an abundant source for miRNA-based biomarkers in human cancers. Despite the fact that an increasing number of potential miRNA biomarkers have been reported, the transition of miRNAs-based biomarkers from bench to bedside still necessitates addressing several challenges. In this review, we will summarize our current understanding of miRNAs as potential biomarkers in human cancers. Hindawi Publishing Corporation 2015 2015-03-22 /pmc/articles/PMC4385606/ /pubmed/25874201 http://dx.doi.org/10.1155/2015/125094 Text en Copyright © 2015 Huiyin Lan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Lan, Huiyin
Lu, Haiqi
Wang, Xian
Jin, Hongchuan
spellingShingle Lan, Huiyin
Lu, Haiqi
Wang, Xian
Jin, Hongchuan
MicroRNAs as Potential Biomarkers in Cancer: Opportunities and Challenges
author_facet Lan, Huiyin
Lu, Haiqi
Wang, Xian
Jin, Hongchuan
author_sort Lan, Huiyin
title MicroRNAs as Potential Biomarkers in Cancer: Opportunities and Challenges
title_short MicroRNAs as Potential Biomarkers in Cancer: Opportunities and Challenges
title_full MicroRNAs as Potential Biomarkers in Cancer: Opportunities and Challenges
title_fullStr MicroRNAs as Potential Biomarkers in Cancer: Opportunities and Challenges
title_full_unstemmed MicroRNAs as Potential Biomarkers in Cancer: Opportunities and Challenges
title_sort micrornas as potential biomarkers in cancer: opportunities and challenges
description MicroRNAs (miRNAs) are a group of small noncoding RNAs (ncRNAs) that posttranscriptionally regulate gene expression by targeting their corresponding messenger RNAs (mRNAs). Dysregulated miRNAs have been considered as a new type of ‘‘oncomiRs” or ‘‘tumor suppressors,” playing essential roles in cancer initiation and progression. Using genome-wide detection methods, ubiquitously aberrant expression profiles of miRNAs have been identified in a broad array of human cancers, showing great potential as novel diagnostic and prognostic biomarkers of cancer with high specificity and sensitivity. The detectable miRNAs in tissue, blood, and other body fluids with high stability provide an abundant source for miRNA-based biomarkers in human cancers. Despite the fact that an increasing number of potential miRNA biomarkers have been reported, the transition of miRNAs-based biomarkers from bench to bedside still necessitates addressing several challenges. In this review, we will summarize our current understanding of miRNAs as potential biomarkers in human cancers.
publisher Hindawi Publishing Corporation
publishDate 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385606/
_version_ 1613207710847729664

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