The Mouse Genome Database (MGD): facilitating mouse as a model for human biology and disease

The Mouse Genome Database (MGD): facilitating mouse as a model for human biology and disease

The Mouse Genome Database (MGD, http://www.informatics.jax.org) serves the international biomedical research community as the central resource for integrated genomic, genetic and biological data on the laboratory mouse. To facilitate use of mouse as a model in translational studies, MGD maintains a...

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Main Authors: Eppig, Janan T., Blake, Judith A., Bult, Carol J., Kadin, James A., Richardson, Joel E.
Format: Online
Language:English
Published: Oxford University Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384027/
id pubmed-4384027
recordtype oai_dc
spelling pubmed-43840272015-04-08 The Mouse Genome Database (MGD): facilitating mouse as a model for human biology and disease Eppig, Janan T. Blake, Judith A. Bult, Carol J. Kadin, James A. Richardson, Joel E. Database Issue The Mouse Genome Database (MGD, http://www.informatics.jax.org) serves the international biomedical research community as the central resource for integrated genomic, genetic and biological data on the laboratory mouse. To facilitate use of mouse as a model in translational studies, MGD maintains a core of high-quality curated data and integrates experimentally and computationally generated data sets. MGD maintains a unified catalog of genes and genome features, including functional RNAs, QTL and phenotypic loci. MGD curates and provides functional and phenotype annotations for mouse genes using the Gene Ontology and Mammalian Phenotype Ontology. MGD integrates phenotype data and associates mouse genotypes to human diseases, providing critical mouse–human relationships and access to repositories holding mouse models. MGD is the authoritative source of nomenclature for genes, genome features, alleles and strains following guidelines of the International Committee on Standardized Genetic Nomenclature for Mice. A new addition to MGD, the Human–Mouse: Disease Connection, allows users to explore gene–phenotype–disease relationships between human and mouse. MGD has also updated search paradigms for phenotypic allele attributes, incorporated incidental mutation data, added a module for display and exploration of genes and microRNA interactions and adopted the JBrowse genome browser. MGD resources are freely available to the scientific community. Oxford University Press 2015-01-28 2014-10-27 /pmc/articles/PMC4384027/ /pubmed/25348401 http://dx.doi.org/10.1093/nar/gku967 Text en © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Eppig, Janan T.
Blake, Judith A.
Bult, Carol J.
Kadin, James A.
Richardson, Joel E.
spellingShingle Eppig, Janan T.
Blake, Judith A.
Bult, Carol J.
Kadin, James A.
Richardson, Joel E.
The Mouse Genome Database (MGD): facilitating mouse as a model for human biology and disease
author_facet Eppig, Janan T.
Blake, Judith A.
Bult, Carol J.
Kadin, James A.
Richardson, Joel E.
author_sort Eppig, Janan T.
title The Mouse Genome Database (MGD): facilitating mouse as a model for human biology and disease
title_short The Mouse Genome Database (MGD): facilitating mouse as a model for human biology and disease
title_full The Mouse Genome Database (MGD): facilitating mouse as a model for human biology and disease
title_fullStr The Mouse Genome Database (MGD): facilitating mouse as a model for human biology and disease
title_full_unstemmed The Mouse Genome Database (MGD): facilitating mouse as a model for human biology and disease
title_sort mouse genome database (mgd): facilitating mouse as a model for human biology and disease
description The Mouse Genome Database (MGD, http://www.informatics.jax.org) serves the international biomedical research community as the central resource for integrated genomic, genetic and biological data on the laboratory mouse. To facilitate use of mouse as a model in translational studies, MGD maintains a core of high-quality curated data and integrates experimentally and computationally generated data sets. MGD maintains a unified catalog of genes and genome features, including functional RNAs, QTL and phenotypic loci. MGD curates and provides functional and phenotype annotations for mouse genes using the Gene Ontology and Mammalian Phenotype Ontology. MGD integrates phenotype data and associates mouse genotypes to human diseases, providing critical mouse–human relationships and access to repositories holding mouse models. MGD is the authoritative source of nomenclature for genes, genome features, alleles and strains following guidelines of the International Committee on Standardized Genetic Nomenclature for Mice. A new addition to MGD, the Human–Mouse: Disease Connection, allows users to explore gene–phenotype–disease relationships between human and mouse. MGD has also updated search paradigms for phenotypic allele attributes, incorporated incidental mutation data, added a module for display and exploration of genes and microRNA interactions and adopted the JBrowse genome browser. MGD resources are freely available to the scientific community.
publisher Oxford University Press
publishDate 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384027/
_version_ 1613207165427777536

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