DoGSD: the dog and wolf genome SNP database

The rapid advancement of next-generation sequencing technology has generated a deluge of genomic data from domesticated dogs and their wild ancestor, grey wolves, which have simultaneously broadened our understanding of domestication and diseases that are shared by humans and dogs. To address the sc...

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Main Authors:	Bai, Bing, Zhao, Wen-Ming, Tang, Bi-Xia, Wang, Yan-Qing, Wang, Lu, Zhang, Zhang, Yang, He-Chuan, Liu, Yan-Hu, Zhu, Jun-Wei, Irwin, David M., Wang, Guo-Dong, Zhang, Ya-Ping
Format:	Online
Language:	English
Published:	Oxford University Press 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383968/

id	pubmed-4383968
recordtype	oai_dc
spelling	pubmed-43839682015-04-08 DoGSD: the dog and wolf genome SNP database Bai, Bing Zhao, Wen-Ming Tang, Bi-Xia Wang, Yan-Qing Wang, Lu Zhang, Zhang Yang, He-Chuan Liu, Yan-Hu Zhu, Jun-Wei Irwin, David M. Wang, Guo-Dong Zhang, Ya-Ping Database Issue The rapid advancement of next-generation sequencing technology has generated a deluge of genomic data from domesticated dogs and their wild ancestor, grey wolves, which have simultaneously broadened our understanding of domestication and diseases that are shared by humans and dogs. To address the scarcity of single nucleotide polymorphism (SNP) data provided by authorized databases and to make SNP data more easily/friendly usable and available, we propose DoGSD (http://dogsd.big.ac.cn), the first canidae-specific database which focuses on whole genome SNP data from domesticated dogs and grey wolves. The DoGSD is a web-based, open-access resource comprising ∼19 million high-quality whole-genome SNPs. In addition to the dbSNP data set (build 139), DoGSD incorporates a comprehensive collection of SNPs from two newly sequenced samples (1 wolf and 1 dog) and collected SNPs from three latest dog/wolf genetic studies (7 wolves and 68 dogs), which were taken together for analysis with the population genetic statistics, Fst. In addition, DoGSD integrates some closely related information including SNP annotation, summary lists of SNPs located in genes, synonymous and non-synonymous SNPs, sampling location and breed information. All these features make DoGSD a useful resource for in-depth analysis in dog-/wolf-related studies. Oxford University Press 2015-01-28 2014-11-17 /pmc/articles/PMC4383968/ /pubmed/25404132 http://dx.doi.org/10.1093/nar/gku1174 Text en © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Bai, Bing Zhao, Wen-Ming Tang, Bi-Xia Wang, Yan-Qing Wang, Lu Zhang, Zhang Yang, He-Chuan Liu, Yan-Hu Zhu, Jun-Wei Irwin, David M. Wang, Guo-Dong Zhang, Ya-Ping
spellingShingle	Bai, Bing Zhao, Wen-Ming Tang, Bi-Xia Wang, Yan-Qing Wang, Lu Zhang, Zhang Yang, He-Chuan Liu, Yan-Hu Zhu, Jun-Wei Irwin, David M. Wang, Guo-Dong Zhang, Ya-Ping DoGSD: the dog and wolf genome SNP database
author_facet	Bai, Bing Zhao, Wen-Ming Tang, Bi-Xia Wang, Yan-Qing Wang, Lu Zhang, Zhang Yang, He-Chuan Liu, Yan-Hu Zhu, Jun-Wei Irwin, David M. Wang, Guo-Dong Zhang, Ya-Ping
author_sort	Bai, Bing
title	DoGSD: the dog and wolf genome SNP database
title_short	DoGSD: the dog and wolf genome SNP database
title_full	DoGSD: the dog and wolf genome SNP database
title_fullStr	DoGSD: the dog and wolf genome SNP database
title_full_unstemmed	DoGSD: the dog and wolf genome SNP database
title_sort	dogsd: the dog and wolf genome snp database
description	The rapid advancement of next-generation sequencing technology has generated a deluge of genomic data from domesticated dogs and their wild ancestor, grey wolves, which have simultaneously broadened our understanding of domestication and diseases that are shared by humans and dogs. To address the scarcity of single nucleotide polymorphism (SNP) data provided by authorized databases and to make SNP data more easily/friendly usable and available, we propose DoGSD (http://dogsd.big.ac.cn), the first canidae-specific database which focuses on whole genome SNP data from domesticated dogs and grey wolves. The DoGSD is a web-based, open-access resource comprising ∼19 million high-quality whole-genome SNPs. In addition to the dbSNP data set (build 139), DoGSD incorporates a comprehensive collection of SNPs from two newly sequenced samples (1 wolf and 1 dog) and collected SNPs from three latest dog/wolf genetic studies (7 wolves and 68 dogs), which were taken together for analysis with the population genetic statistics, Fst. In addition, DoGSD integrates some closely related information including SNP annotation, summary lists of SNPs located in genes, synonymous and non-synonymous SNPs, sampling location and breed information. All these features make DoGSD a useful resource for in-depth analysis in dog-/wolf-related studies.
publisher	Oxford University Press
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383968/
_version_	1613207131152973824

DoGSD: the dog and wolf genome SNP database

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