IL-23-mediated mononuclear phagocyte crosstalk protects mice from Citrobacter rodentium-induced colon immunopathology

IL-23-mediated mononuclear phagocyte crosstalk protects mice from Citrobacter rodentium-induced colon immunopathology

Gut homeostasis and mucosal immune defense rely on the differential contributions of dendritic cells (DC) and macrophages. Here we show that colonic CX3CR1+ mononuclear phagocytes are critical inducers of the innate response to Citrobacter rodentium infection. Specifically, the absence of IL-23 expr...

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Bibliographic Details
Main Authors: Aychek, Tegest, Mildner, Alexander, Yona, Simon, Kim, Ki-Wook, Lampl, Nardy, Reich-Zeliger, Shlomit, Boon, Louis, Yogev, Nir, Waisman, Ari, Cua, Daniel J., Jung, Steffen
Format: Online
Language:English
Published: Nature Pub. Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382688/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382688/

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