TRPM8 on mucosal sensory nerves regulates colitogenic responses by innate immune cells via CGRP

TRPM8 on mucosal sensory nerves regulates colitogenic responses by innate immune cells via CGRP

TRPM8 is the molecular sensor for cold; however, the physiological role of TRPM8+ neurons at mucosal surfaces is unclear. Here we evaluated the distribution and peptidergic properties of TRPM8+ fibers in naïve and inflamed colons, as well as their role in mucosal inflammation. We found that Trpm8−/−...

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Bibliographic Details
Main Authors: de Jong, Petrus R., Takahashi, Naoki, Peiris, Madusha, Bertin, Samuel, Lee, Jihyung, Gareau, Melanie G., Paniagua, Alan, Harris, Alexandra R., Herdman, David S., Corr, Maripat, Blackshaw, L. Ashley, Raz, Eyal
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382463/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382463/

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