Discovery and Cardioprotective Effects of the First Non-Peptide Agonists of the G Protein-Coupled Prokineticin Receptor-1

Discovery and Cardioprotective Effects of the First Non-Peptide Agonists of the G Protein-Coupled Prokineticin Receptor-1

Prokineticins are angiogenic hormones that activate two G protein-coupled receptors: PKR1 and PKR2. PKR1 has emerged as a critical mediator of cardiovascular homeostasis and cardioprotection. Identification of non-peptide PKR1 agonists that contribute to myocardial repair and collateral vessel growt...

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Bibliographic Details
Main Authors: Gasser, Adeline, Brogi, Simone, Urayama, Kyoji, Nishi, Toshishide, Kurose, Hitoshi, Tafi, Andrea, Ribeiro, Nigel, Désaubry, Laurent, Nebigil, Canan G.
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382091/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382091/

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