Downregulation of Wnt signaling by sonic hedgehog activation promotes repopulation of human tumor cell lines

Tumor repopulation after radiotherapy is a big obstacle for clinical cancer therapy. The molecular mechanisms of tumor cell repopulation after radiotherapy remain unclear. This study investigated the role of sonic hedgehog (SHH) and Wnt signaling pathways in tumor repopulation after radiotherapy in...

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Bibliographic Details
Main Authors: Ma, Jingjing, Cheng, Jin, Gong, Yanping, Tian, Ling, Huang, Qian
Format: Online
Language:English
Published: The Company of Biologists Limited 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381337/