Epigenetic changes in the CDKN2A locus are associated with differential expression of P16INK4A and P14ARF in HPV-positive oropharyngeal squamous cell carcinoma

Epigenetic changes in the CDKN2A locus are associated with differential expression of P16INK4A and P14ARF in HPV-positive oropharyngeal squamous cell carcinoma

Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is recognized as a distinct disease entity associated with improved survival. DNA hypermethylation profiles differ significantly by HPV status suggesting that a specific subset of methylated CpG loci could give mechani...

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Bibliographic Details
Main Authors: Schlecht, Nicolas F, Ben-Dayan, Miriam, Anayannis, Nicole, Lleras, Roberto A, Thomas, Carlos, Wang, Yanhua, Smith, Richard V, Burk, Robert D, Harris, Thomas M, Childs, Geoffrey, Ow, Thomas J, Prystowsky, Michael B, Belbin, Thomas J
Format: Online
Language:English
Published: BlackWell Publishing Ltd 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380960/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380960/

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