Impairment of Type I but Not Type III IFN Signaling by Hepatitis C Virus Infection Influences Antiviral Responses in Primary Human Hepatocytes

Impairment of Type I but Not Type III IFN Signaling by Hepatitis C Virus Infection Influences Antiviral Responses in Primary Human Hepatocytes

Peginterferon lambda-1a (Lambda), a type III interferon (IFN), acts through a unique receptor complex with limited cellular expression outside the liver which may result in a differentiated tolerability profile compared to peginterferon alfa (alfa). In Phase 2b clinical studies, Lambda administered...

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Bibliographic Details
Main Authors: Friborg, Jacques, Ross-Macdonald, Petra, Cao, Jian, Willard, Ryan, Lin, Baiqing, Eggers, Betsy, McPhee, Fiona
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380495/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380495/

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