Dose–volume histogram comparison between static 5-field IMRT with 18-MV X-rays and helical tomotherapy with 6-MV X-rays

We treated prostate cancer patients with static 5-field intensity-modulated radiation therapy (IMRT) using linac 18-MV X-rays or tomotherapy with 6-MV X-rays. As X-ray energies differ, we hypothesized that 18-MV photon IMRT may be better for large patients and tomotherapy may be more suitable for sm...

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Main Authors:	Hayashi, Akihiro, Shibamoto, Yuta, Hattori, Yukiko, Tamura, Takeshi, Iwabuchi, Michio, Otsuka, Shinya, Sugie, Chikao, Yanagi, Takeshi
Format:	Online
Language:	English
Published:	Oxford University Press 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380056/

id	pubmed-4380056
recordtype	oai_dc
spelling	pubmed-43800562015-04-15 Dose–volume histogram comparison between static 5-field IMRT with 18-MV X-rays and helical tomotherapy with 6-MV X-rays Hayashi, Akihiro Shibamoto, Yuta Hattori, Yukiko Tamura, Takeshi Iwabuchi, Michio Otsuka, Shinya Sugie, Chikao Yanagi, Takeshi Oncology We treated prostate cancer patients with static 5-field intensity-modulated radiation therapy (IMRT) using linac 18-MV X-rays or tomotherapy with 6-MV X-rays. As X-ray energies differ, we hypothesized that 18-MV photon IMRT may be better for large patients and tomotherapy may be more suitable for small patients. Thus, we compared dose–volume parameters for the planning target volume (PTV) and organs at risk (OARs) in 59 patients with T1–3 N0M0 prostate cancer who had been treated using 5-field IMRT. For these same patients, tomotherapy plans were also prepared for comparison. In addition, plans of 18 patients who were actually treated with tomotherapy were analyzed. The evaluated parameters were homogeneity indicies and a conformity index for the PTVs, and D2 (dose received by 2% of the PTV in Gy), D98, Dmean and V10–70 Gy (%) for OARs. To evaluate differences by body size, patients with a known body mass index were grouped by that index ( <21; 21–25; and >25 kg/m2). For the PTV, all parameters were higher in the tomotherapy plans compared with the 5-field IMRT plans. For the rectum, V10 Gy and V60 Gy were higher, whereas V20 Gy and V30 Gy were lower in the tomotherapy plans. For the bladder, all parameters were higher in the tomotherapy plans. However, both plans were considered clinically acceptable. Similar trends were observed in 18 patients treated with tomotherapy. Obvious trends were not observed for body size. Tomotherapy provides equivalent dose distributions for PTVs and OARs compared with 18-MV 5-field IMRT. Tomotherapy could be used as a substitute for high-energy photon IMRT for prostate cancer regardless of body size. Oxford University Press 2015-03 2015-01-20 /pmc/articles/PMC4380056/ /pubmed/25609741 http://dx.doi.org/10.1093/jrr/rru111 Text en © The Author 2015. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Hayashi, Akihiro Shibamoto, Yuta Hattori, Yukiko Tamura, Takeshi Iwabuchi, Michio Otsuka, Shinya Sugie, Chikao Yanagi, Takeshi
spellingShingle	Hayashi, Akihiro Shibamoto, Yuta Hattori, Yukiko Tamura, Takeshi Iwabuchi, Michio Otsuka, Shinya Sugie, Chikao Yanagi, Takeshi Dose–volume histogram comparison between static 5-field IMRT with 18-MV X-rays and helical tomotherapy with 6-MV X-rays
author_facet	Hayashi, Akihiro Shibamoto, Yuta Hattori, Yukiko Tamura, Takeshi Iwabuchi, Michio Otsuka, Shinya Sugie, Chikao Yanagi, Takeshi
author_sort	Hayashi, Akihiro
title	Dose–volume histogram comparison between static 5-field IMRT with 18-MV X-rays and helical tomotherapy with 6-MV X-rays
title_short	Dose–volume histogram comparison between static 5-field IMRT with 18-MV X-rays and helical tomotherapy with 6-MV X-rays
title_full	Dose–volume histogram comparison between static 5-field IMRT with 18-MV X-rays and helical tomotherapy with 6-MV X-rays
title_fullStr	Dose–volume histogram comparison between static 5-field IMRT with 18-MV X-rays and helical tomotherapy with 6-MV X-rays
title_full_unstemmed	Dose–volume histogram comparison between static 5-field IMRT with 18-MV X-rays and helical tomotherapy with 6-MV X-rays
title_sort	dose–volume histogram comparison between static 5-field imrt with 18-mv x-rays and helical tomotherapy with 6-mv x-rays
description	We treated prostate cancer patients with static 5-field intensity-modulated radiation therapy (IMRT) using linac 18-MV X-rays or tomotherapy with 6-MV X-rays. As X-ray energies differ, we hypothesized that 18-MV photon IMRT may be better for large patients and tomotherapy may be more suitable for small patients. Thus, we compared dose–volume parameters for the planning target volume (PTV) and organs at risk (OARs) in 59 patients with T1–3 N0M0 prostate cancer who had been treated using 5-field IMRT. For these same patients, tomotherapy plans were also prepared for comparison. In addition, plans of 18 patients who were actually treated with tomotherapy were analyzed. The evaluated parameters were homogeneity indicies and a conformity index for the PTVs, and D2 (dose received by 2% of the PTV in Gy), D98, Dmean and V10–70 Gy (%) for OARs. To evaluate differences by body size, patients with a known body mass index were grouped by that index ( <21; 21–25; and >25 kg/m2). For the PTV, all parameters were higher in the tomotherapy plans compared with the 5-field IMRT plans. For the rectum, V10 Gy and V60 Gy were higher, whereas V20 Gy and V30 Gy were lower in the tomotherapy plans. For the bladder, all parameters were higher in the tomotherapy plans. However, both plans were considered clinically acceptable. Similar trends were observed in 18 patients treated with tomotherapy. Obvious trends were not observed for body size. Tomotherapy provides equivalent dose distributions for PTVs and OARs compared with 18-MV 5-field IMRT. Tomotherapy could be used as a substitute for high-energy photon IMRT for prostate cancer regardless of body size.
publisher	Oxford University Press
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380056/
_version_	1613205780084817920

Dose–volume histogram comparison between static 5-field IMRT with 18-MV X-rays and helical tomotherapy with 6-MV X-rays

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