Low-frequency connectivity is associated with mild traumatic brain injury

Mild traumatic brain injury (mTBI) occurs from a closed-head impact. Often referred to as concussion, about 20% of cases complain of secondary psychological sequelae, such as disorders of attention and memory. Known as post-concussive symptoms (PCS), these problems can severely disrupt the patient&#...

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Main Authors:	Dunkley, B.T., Da Costa, L., Bethune, A., Jetly, R., Pang, E.W., Taylor, M.J., Doesburg, S.M.
Format:	Online
Language:	English
Published:	Elsevier 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379387/

id	pubmed-4379387
recordtype	oai_dc
spelling	pubmed-43793872015-04-03 Low-frequency connectivity is associated with mild traumatic brain injury Dunkley, B.T. Da Costa, L. Bethune, A. Jetly, R. Pang, E.W. Taylor, M.J. Doesburg, S.M. Regular Article Mild traumatic brain injury (mTBI) occurs from a closed-head impact. Often referred to as concussion, about 20% of cases complain of secondary psychological sequelae, such as disorders of attention and memory. Known as post-concussive symptoms (PCS), these problems can severely disrupt the patient's quality of life. Changes in local spectral power, particularly low-frequency amplitude increases and/or peak alpha slowing have been reported in mTBI, but large-scale connectivity metrics based on inter-regional amplitude correlations relevant for integration and segregation in functional brain networks, and their association with disorders in cognition and behaviour, remain relatively unexplored. Here, we used non-invasive neuroimaging with magnetoencephalography to examine functional connectivity in a resting-state protocol in a group with mTBI (n = 20), and a control group (n = 21). We observed a trend for atypical slow-wave power changes in subcortical, temporal and parietal regions in mTBI, as well as significant long-range increases in amplitude envelope correlations among deep-source, temporal, and frontal regions in the delta, theta, and alpha bands. Subsequently, we conducted an exploratory analysis of patterns of connectivity most associated with variability in secondary symptoms of mTBI, including inattention, anxiety, and depression. Differential patterns of altered resting state neurophysiological network connectivity were found across frequency bands. This indicated that multiple network and frequency specific alterations in large scale brain connectivity may contribute to overlapping cognitive sequelae in mTBI. In conclusion, we show that local spectral power content can be supplemented with measures of correlations in amplitude to define general networks that are atypical in mTBI, and suggest that certain cognitive difficulties are mediated by disturbances in a variety of alterations in network interactions which are differentially expressed across canonical neurophysiological frequency ranges. Elsevier 2015-03-03 /pmc/articles/PMC4379387/ /pubmed/25844315 http://dx.doi.org/10.1016/j.nicl.2015.02.020 Text en Crown Copyright © 2015 Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Dunkley, B.T. Da Costa, L. Bethune, A. Jetly, R. Pang, E.W. Taylor, M.J. Doesburg, S.M.
spellingShingle	Dunkley, B.T. Da Costa, L. Bethune, A. Jetly, R. Pang, E.W. Taylor, M.J. Doesburg, S.M. Low-frequency connectivity is associated with mild traumatic brain injury
author_facet	Dunkley, B.T. Da Costa, L. Bethune, A. Jetly, R. Pang, E.W. Taylor, M.J. Doesburg, S.M.
author_sort	Dunkley, B.T.
title	Low-frequency connectivity is associated with mild traumatic brain injury
title_short	Low-frequency connectivity is associated with mild traumatic brain injury
title_full	Low-frequency connectivity is associated with mild traumatic brain injury
title_fullStr	Low-frequency connectivity is associated with mild traumatic brain injury
title_full_unstemmed	Low-frequency connectivity is associated with mild traumatic brain injury
title_sort	low-frequency connectivity is associated with mild traumatic brain injury
description	Mild traumatic brain injury (mTBI) occurs from a closed-head impact. Often referred to as concussion, about 20% of cases complain of secondary psychological sequelae, such as disorders of attention and memory. Known as post-concussive symptoms (PCS), these problems can severely disrupt the patient's quality of life. Changes in local spectral power, particularly low-frequency amplitude increases and/or peak alpha slowing have been reported in mTBI, but large-scale connectivity metrics based on inter-regional amplitude correlations relevant for integration and segregation in functional brain networks, and their association with disorders in cognition and behaviour, remain relatively unexplored. Here, we used non-invasive neuroimaging with magnetoencephalography to examine functional connectivity in a resting-state protocol in a group with mTBI (n = 20), and a control group (n = 21). We observed a trend for atypical slow-wave power changes in subcortical, temporal and parietal regions in mTBI, as well as significant long-range increases in amplitude envelope correlations among deep-source, temporal, and frontal regions in the delta, theta, and alpha bands. Subsequently, we conducted an exploratory analysis of patterns of connectivity most associated with variability in secondary symptoms of mTBI, including inattention, anxiety, and depression. Differential patterns of altered resting state neurophysiological network connectivity were found across frequency bands. This indicated that multiple network and frequency specific alterations in large scale brain connectivity may contribute to overlapping cognitive sequelae in mTBI. In conclusion, we show that local spectral power content can be supplemented with measures of correlations in amplitude to define general networks that are atypical in mTBI, and suggest that certain cognitive difficulties are mediated by disturbances in a variety of alterations in network interactions which are differentially expressed across canonical neurophysiological frequency ranges.
publisher	Elsevier
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379387/
_version_	1613205514489954304

Low-frequency connectivity is associated with mild traumatic brain injury

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