Dose-Dependent Dual Role of PIT-1 (POU1F1) in Somatolactotroph Cell Proliferation and Apoptosis

Dose-Dependent Dual Role of PIT-1 (POU1F1) in Somatolactotroph Cell Proliferation and Apoptosis

To test the role of wtPIT-1 (PITWT) or PIT-1 (R271W) (PIT271) in somatolactotroph cells, we established, using inducible lentiviral vectors, sublines of GH4C1 somatotroph cells that allow the blockade of the expression of endogenous PIT-1 and/or the expression of PITWT or PIT271, a dominant negative...

Full description

Bibliographic Details
Main Authors: Jullien, Nicolas, Roche, Catherine, Brue, Thierry, Figarella-Branger, Dominique, Graillon, Thomas, Barlier, Anne, Herman, Jean-Paul
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379079/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379079/

Similar Items