Serum Cholesterol Reduction Efficacy of Biscuits with Added Plant Stanol Ester

This study's aim was to test the low-density lipoprotein cholesterol- (LDL-c-) lowering efficacy of biscuits containing 2 g of plant stanols, which corresponded to 3.4 g of plant stanol esters. The biscuit is a new food format that can be consumed as a snack. In a double-blind, placebo-controll...

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Main Authors:	Kriengsinyos, Wantanee, Wangtong, Ajima, Komindr, Surat
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377436/

id	pubmed-4377436
recordtype	oai_dc
spelling	pubmed-43774362015-04-08 Serum Cholesterol Reduction Efficacy of Biscuits with Added Plant Stanol Ester Kriengsinyos, Wantanee Wangtong, Ajima Komindr, Surat Clinical Study This study's aim was to test the low-density lipoprotein cholesterol- (LDL-c-) lowering efficacy of biscuits containing 2 g of plant stanols, which corresponded to 3.4 g of plant stanol esters. The biscuit is a new food format that can be consumed as a snack. In a double-blind, placebo-controlled parallel design study, 119 mildly to moderately hypercholesterolemic volunteers were randomized to plant stanol or control groups. Subjects were comparable in age, gender, lipid profiles, and body mass index. They consumed a control biscuit once a day for a two-week period, followed by a four-week intervention period that either had a plant stanol ester biscuit or a control. During the habitual diet, one biscuit per day was consumed at any time that subjects wished. Serum lipid profiles were measured at the first day of run-in, at baseline, and at the study's end. Compared to the control, the total cholesterol (TC), LDL-c, and the LDL-to-high-density lipoprotein (LDL/HDL) ratio had serum reductions of 4.9%, 6.1%, and 4.3%, respectively, and were observed after 4 weeks of biscuit consumption with added plant stanols (P < 0.05). A significantly higher reduction in LDL-c (8.9%) and LDL/HDL ratio (11.4%) was measured in those taking a plant stanol biscuit with a meal compared to those who consumed a plant stanol biscuit without other food. In conclusion, incorporating plant stanols into a biscuit is an attractive, convenient, and acceptable way to modestly lower elevated cholesterol concentrations. For optimal efficacy, biscuits should be consumed with a meal as part of a healthy diet. Hindawi Publishing Corporation 2015 2015-03-10 /pmc/articles/PMC4377436/ /pubmed/25861469 http://dx.doi.org/10.1155/2015/353164 Text en Copyright © 2015 Wantanee Kriengsinyos et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Kriengsinyos, Wantanee Wangtong, Ajima Komindr, Surat
spellingShingle	Kriengsinyos, Wantanee Wangtong, Ajima Komindr, Surat Serum Cholesterol Reduction Efficacy of Biscuits with Added Plant Stanol Ester
author_facet	Kriengsinyos, Wantanee Wangtong, Ajima Komindr, Surat
author_sort	Kriengsinyos, Wantanee
title	Serum Cholesterol Reduction Efficacy of Biscuits with Added Plant Stanol Ester
title_short	Serum Cholesterol Reduction Efficacy of Biscuits with Added Plant Stanol Ester
title_full	Serum Cholesterol Reduction Efficacy of Biscuits with Added Plant Stanol Ester
title_fullStr	Serum Cholesterol Reduction Efficacy of Biscuits with Added Plant Stanol Ester
title_full_unstemmed	Serum Cholesterol Reduction Efficacy of Biscuits with Added Plant Stanol Ester
title_sort	serum cholesterol reduction efficacy of biscuits with added plant stanol ester
description	This study's aim was to test the low-density lipoprotein cholesterol- (LDL-c-) lowering efficacy of biscuits containing 2 g of plant stanols, which corresponded to 3.4 g of plant stanol esters. The biscuit is a new food format that can be consumed as a snack. In a double-blind, placebo-controlled parallel design study, 119 mildly to moderately hypercholesterolemic volunteers were randomized to plant stanol or control groups. Subjects were comparable in age, gender, lipid profiles, and body mass index. They consumed a control biscuit once a day for a two-week period, followed by a four-week intervention period that either had a plant stanol ester biscuit or a control. During the habitual diet, one biscuit per day was consumed at any time that subjects wished. Serum lipid profiles were measured at the first day of run-in, at baseline, and at the study's end. Compared to the control, the total cholesterol (TC), LDL-c, and the LDL-to-high-density lipoprotein (LDL/HDL) ratio had serum reductions of 4.9%, 6.1%, and 4.3%, respectively, and were observed after 4 weeks of biscuit consumption with added plant stanols (P < 0.05). A significantly higher reduction in LDL-c (8.9%) and LDL/HDL ratio (11.4%) was measured in those taking a plant stanol biscuit with a meal compared to those who consumed a plant stanol biscuit without other food. In conclusion, incorporating plant stanols into a biscuit is an attractive, convenient, and acceptable way to modestly lower elevated cholesterol concentrations. For optimal efficacy, biscuits should be consumed with a meal as part of a healthy diet.
publisher	Hindawi Publishing Corporation
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377436/
_version_	1613204844227592192

Serum Cholesterol Reduction Efficacy of Biscuits with Added Plant Stanol Ester

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