Upgrading prostate cancer following proton beam therapy

Pre- and post-radiation therapy (RT) effects on prostate histology have not been rigorously studied, but there appears to be a correlation between escalating radiation dosage and increasing post-RT histologic changes. Despite this dose-response relationship, radiation-induced changes may be heteroge...

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Main Authors:	Logan, Jennifer K., Rais-Bahrami, Soroush, Merino, Maria J., Pinto, Peter A.
Format:	Online
Language:	English
Published:	Medknow Publications & Media Pvt Ltd 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374273/

id	pubmed-4374273
recordtype	oai_dc
spelling	pubmed-43742732015-04-01 Upgrading prostate cancer following proton beam therapy Logan, Jennifer K. Rais-Bahrami, Soroush Merino, Maria J. Pinto, Peter A. Case Report Pre- and post-radiation therapy (RT) effects on prostate histology have not been rigorously studied, but there appears to be a correlation between escalating radiation dosage and increasing post-RT histologic changes. Despite this dose-response relationship, radiation-induced changes may be heterogenous among different patients and even within a single tumor. When assessing residual tumor it is important to understand biopsy evaluation in the post-RT setting. We present the case of a poorly differentiated prostate adenocarcinoma following proton beam RT in a 45-year-old man with pre-RT Gleason 4 + 3 = 7 disease diagnosed in the setting of an elevated serum prostate-specific antigen level. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4374273/ /pubmed/25837674 http://dx.doi.org/10.4103/0974-7796.152944 Text en Copyright: © Urology Annals http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Logan, Jennifer K. Rais-Bahrami, Soroush Merino, Maria J. Pinto, Peter A.
spellingShingle	Logan, Jennifer K. Rais-Bahrami, Soroush Merino, Maria J. Pinto, Peter A. Upgrading prostate cancer following proton beam therapy
author_facet	Logan, Jennifer K. Rais-Bahrami, Soroush Merino, Maria J. Pinto, Peter A.
author_sort	Logan, Jennifer K.
title	Upgrading prostate cancer following proton beam therapy
title_short	Upgrading prostate cancer following proton beam therapy
title_full	Upgrading prostate cancer following proton beam therapy
title_fullStr	Upgrading prostate cancer following proton beam therapy
title_full_unstemmed	Upgrading prostate cancer following proton beam therapy
title_sort	upgrading prostate cancer following proton beam therapy
description	Pre- and post-radiation therapy (RT) effects on prostate histology have not been rigorously studied, but there appears to be a correlation between escalating radiation dosage and increasing post-RT histologic changes. Despite this dose-response relationship, radiation-induced changes may be heterogenous among different patients and even within a single tumor. When assessing residual tumor it is important to understand biopsy evaluation in the post-RT setting. We present the case of a poorly differentiated prostate adenocarcinoma following proton beam RT in a 45-year-old man with pre-RT Gleason 4 + 3 = 7 disease diagnosed in the setting of an elevated serum prostate-specific antigen level.
publisher	Medknow Publications & Media Pvt Ltd
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374273/
_version_	1613203729019830272

Upgrading prostate cancer following proton beam therapy

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