TopBP1 Interacts with BLM to Maintain Genome Stability but Is Dispensable for Preventing BLM Degradation

TopBP1 Interacts with BLM to Maintain Genome Stability but Is Dispensable for Preventing BLM Degradation

The Bloom syndrome helicase BLM and topoisomerase-IIβ-binding protein 1 (TopBP1) are key regulators of genome stability. It was recently proposed that BLM phosphorylation on Ser338 mediates its interaction with TopBP1, to protect BLM from ubiquitylation and degradation (Wang et al., 2013). Here, we...

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Bibliographic Details
Main Authors: Blackford, Andrew N., Nieminuszczy, Jadwiga, Schwab, Rebekka A., Galanty, Yaron, Jackson, Stephen P., Niedzwiedz, Wojciech
Format: Online
Language:English
Published: Cell Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374139/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374139/

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