Clonal Evolution Revealed by Whole Genome Sequencing in a Case of Primary Myelofibrosis Transformed to Secondary Acute Myeloid Leukemia

Clonal Evolution Revealed by Whole Genome Sequencing in a Case of Primary Myelofibrosis Transformed to Secondary Acute Myeloid Leukemia

Clonal architecture in myeloproliferative neoplasms (MPNs) is poorly understood. Here we report genomic analyses of a patient with primary myelofibrosis (PMF) transformed to secondary acute myeloid leukemia (sAML). Whole genome sequencing (WGS) was performed on PMF and sAML diagnosis samples, with s...

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Bibliographic Details
Main Authors: Engle, Elizabeth K., Fisher, Daniel A.C., Miller, Christopher A., McLellan, Michael D., Fulton, Robert S., Moore, Deborah M., Wilson, Richard K., Ley, Timothy J., Oh, Stephen T.
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374044/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374044/

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