The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics
It has been almost 25 years since the initial discovery that tau was the primary component of the neurofibrillary tangles (NFTs) in Alzheimer disease (AD) brain. Although AD is defined by both β-amyloid (Aβ) pathology (Aβ plaques) and tau pathology (NFTs), whether or not tau played a critical role i...
| Main Authors: | , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Blackwell Publishing Ltd
2011
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373356/ |