MicroRNA399 is involved in multiple nutrient starvation responses in rice

The increasing evidences have revealed that microRNAs (miRNAs) play significant role in nutrient stress response. Previously, miR399 was documented to be induced by phosphorus (P) starvation and involved in regulating P starvation responses. To further investigate the function of miR399 in rice (Ory...

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Main Authors:	Hu, Bin, Wang, Wei, Deng, Kun, Li, Hua, Zhang, Zhihua, Zhang, Lianhe, Chu, Chengcai
Format:	Online
Language:	English
Published:	Frontiers Media S.A. 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371656/

id	pubmed-4371656
recordtype	oai_dc
spelling	pubmed-43716562015-04-07 MicroRNA399 is involved in multiple nutrient starvation responses in rice Hu, Bin Wang, Wei Deng, Kun Li, Hua Zhang, Zhihua Zhang, Lianhe Chu, Chengcai Plant Science The increasing evidences have revealed that microRNAs (miRNAs) play significant role in nutrient stress response. Previously, miR399 was documented to be induced by phosphorus (P) starvation and involved in regulating P starvation responses. To further investigate the function of miR399 in rice (Oryza sativa L.), we performed GeneChip analysis with OsmiR399 over-expressing plants. Interestingly, our results showed that, besides P starvation responsive genes, the expression of a number of genes involved in iron (Fe), potassium (K), sodium (Na), and calcium (Ca) absorption was dramatically up-regulated in OsmiR399 over-expressing plants. Consistently, the concentrations of Fe, K, Na, and Ca were also increased in OsmiR399 over-expressing plants. The expression of OsmiR399 was also up-regulated by these nutrient starvations, respectively. Moreover, the loss-of-function of LTN1, the down-stream target of OsmiR399, also resulted in the increase of multiple metal elements and the up-regulation of the absorption related genes. These results indicated that OsmiR399 participates in the regulation of multiple nutrient starvation responses, which also gives new view on understanding the interaction among different nutrients mediated by miR399. Frontiers Media S.A. 2015-03-24 /pmc/articles/PMC4371656/ /pubmed/25852730 http://dx.doi.org/10.3389/fpls.2015.00188 Text en Copyright © 2015 Hu, Wang, Deng, Li, Zhang, Zhang and Chu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Hu, Bin Wang, Wei Deng, Kun Li, Hua Zhang, Zhihua Zhang, Lianhe Chu, Chengcai
spellingShingle	Hu, Bin Wang, Wei Deng, Kun Li, Hua Zhang, Zhihua Zhang, Lianhe Chu, Chengcai MicroRNA399 is involved in multiple nutrient starvation responses in rice
author_facet	Hu, Bin Wang, Wei Deng, Kun Li, Hua Zhang, Zhihua Zhang, Lianhe Chu, Chengcai
author_sort	Hu, Bin
title	MicroRNA399 is involved in multiple nutrient starvation responses in rice
title_short	MicroRNA399 is involved in multiple nutrient starvation responses in rice
title_full	MicroRNA399 is involved in multiple nutrient starvation responses in rice
title_fullStr	MicroRNA399 is involved in multiple nutrient starvation responses in rice
title_full_unstemmed	MicroRNA399 is involved in multiple nutrient starvation responses in rice
title_sort	microrna399 is involved in multiple nutrient starvation responses in rice
description	The increasing evidences have revealed that microRNAs (miRNAs) play significant role in nutrient stress response. Previously, miR399 was documented to be induced by phosphorus (P) starvation and involved in regulating P starvation responses. To further investigate the function of miR399 in rice (Oryza sativa L.), we performed GeneChip analysis with OsmiR399 over-expressing plants. Interestingly, our results showed that, besides P starvation responsive genes, the expression of a number of genes involved in iron (Fe), potassium (K), sodium (Na), and calcium (Ca) absorption was dramatically up-regulated in OsmiR399 over-expressing plants. Consistently, the concentrations of Fe, K, Na, and Ca were also increased in OsmiR399 over-expressing plants. The expression of OsmiR399 was also up-regulated by these nutrient starvations, respectively. Moreover, the loss-of-function of LTN1, the down-stream target of OsmiR399, also resulted in the increase of multiple metal elements and the up-regulation of the absorption related genes. These results indicated that OsmiR399 participates in the regulation of multiple nutrient starvation responses, which also gives new view on understanding the interaction among different nutrients mediated by miR399.
publisher	Frontiers Media S.A.
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371656/
_version_	1613202756506484736

MicroRNA399 is involved in multiple nutrient starvation responses in rice

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