Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling

Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling

Angiopoietin-like proteins (angptls) are capable of ex vivo expansion of mouse and human hematopoietic stem and progenitor cells (HSPCs). Despite this intriguing ability, their mechanism is unknown. In this study, we show that angptl2 overexpression is sufficient to expand definitive HSPCs in zebraf...

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Bibliographic Details
Main Authors: Lin, Michelle I, Price, Emily N, Boatman, Sonja, Hagedorn, Elliott J, Trompouki, Eirini, Satishchandran, Sruthi, Carspecken, Charles W, Uong, Audrey, DiBiase, Anthony, Yang, Song, Canver, Matthew C, Dahlberg, Ann, Lu, Zhigang, Zhang, Cheng Cheng, Orkin, Stuart H, Bernstein, Irwin D, Aster, Jon C, White, Richard M, Zon, Leonard I
Format: Online
Language:English
Published: eLife Sciences Publications, Ltd 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371382/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371382/

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