Low Shear Stress Induced HMGB1 Translocation and Release via PECAM-1/PARP-1 Pathway to Induce Inflammation Response

Low Shear Stress Induced HMGB1 Translocation and Release via PECAM-1/PARP-1 Pathway to Induce Inflammation Response

Low shear stress (LSS) plays a critical role in the site predilection of atherosclerosis through activation of cellular mechanosensors, such as platelet endothelial cell adhesion molecule 1 (PECAM-1). Poly(ADP-ribose) polymerase 1 (PARP-1) is a nuclear enzyme that regulates the expression of various...

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Bibliographic Details
Main Authors: Qin, Wei-dong, Mi, Shao-hua, Li, Chen, Wang, Gui-xia, Zhang, Jian-ning, Wang, Hao, Zhang, Fan, Ma, Yang, Wu, Da-wei, Zhang, Mingxiang
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368774/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368774/

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