Aberrant Expression of PHLPP1 and PHLPP2 Correlates with Poor Prognosis in Patients with Hypopharyngeal Squamous Cell Carcinoma

Aberrant Expression of PHLPP1 and PHLPP2 Correlates with Poor Prognosis in Patients with Hypopharyngeal Squamous Cell Carcinoma

The PHLPP (pleckstrin homology [PH] domain leucine rich repeat protein phosphatase) family, which represents a family of novel Ser/Thr protein phosphatases, is composed of 2 members: PHLPP1 and PHLPP2. PHLPPs partake in diverse cellular activities to exhibit their antitumor and metastasis suppressor...

Full description

Bibliographic Details
Main Authors:	Zhou, Jieyu, Yu, Xuemin, Wang, Juan, Li, Tao, Jin, Tong, Lei, Dapeng, Pan, Xinliang
Format:	Online
Language:	English
Published:	Public Library of Science 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368744/

Similar Items

Aberrant Expression of Beclin-1 and LC3 Correlates with Poor Prognosis of Human Hypopharyngeal Squamous Cell Carcinoma
by: Wang, Juan, et al.
Published: (2013)

Caveolin-1 is overexpressed in hypopharyngeal squamous cell carcinoma and correlates with clinical parameters
by: Zhao, Xuening, et al.
Published: (2016)

Detection of PHLPP1α/β in Human and Mouse Brain by Different Anti-PHLPP1 Antibodies
by: Jackson, Travis C., et al.
Published: (2015)

High PHLPP expression is associated with better prognosis in patients with resected lung adenocarcinoma
by: Lv, Dongqing, et al.
Published: (2015)

Mechanisms and consequences of the loss of PHLPP1 phosphatase in chronic lymphocytic leukemia (CLL)
by: O'Hayre, M, et al.
Published: (2012)

AB209630, a long non-coding RNA decreased expression in hypopharyngeal squamous cell carcinoma, influences proliferation, invasion, metastasis, and survival
by: Zhou, Jieyu, et al.
Published: (2016)

Preservation of laryngeal function improves outcomes of patients with hypopharyngeal carcinoma
by: Jin, Tong, et al.
Published: (2014)

The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer
by: Li, Xin, et al.
Published: (2012)

PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma
by: Molina, Jennifer R., et al.
Published: (2011)

PHLPP2 suppresses the NF-κB pathway by inactivating IKKβ kinase
by: Agarwal, Nitin Kumar, et al.
Published: (2014)

Xist reduction in breast cancer upregulates AKT phosphorylation via HDAC3-mediated repression of PHLPP1 expression
by: Huang, Yen-Sung, et al.
Published: (2016)

SCOP/PHLPP1β in the basolateral amygdala regulates circadian expression of mouse anxiety-like behavior
by: Nakano, Jun J., et al.
Published: (2016)

SCOP/PHLPP1β mediates circadian regulation of long-term recognition memory
by: Shimizu, Kimiko, et al.
Published: (2016)

Protein phosphatase PHLPP induces cell apoptosis and exerts anticancer activity by inhibiting Survivin phosphorylation and nuclear export in gallbladder cancer
by: Qiu, Yinghe, et al.
Published: (2015)

PHLPP1 phosphatase inhibition in hypothalamus restores insulin signaling and action and reduces adiposity in obese rats
by: dos Santos Cardoso, Bruna, et al.
Published: (2015)

Lysosomal mTORC2/PHLPP1/Akt axis: a new point of control of chaperone-mediated autophagy
by: Arias, Esperanza
Published: (2015)

mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2
by: Kim, KyeongJin, et al.
Published: (2016)

PHLPP negatively regulates cell motility through inhibition of Akt activity and integrin expression in pancreatic cancer cells
by: Smith, Alena J., et al.
Published: (2016)

Mutual inhibition of insulin signaling and PHLPP-1 determines cardioprotective efficiency of Akt in aged heart
by: Xing, Yuan, et al.
Published: (2016)

Prognostic significance of claudin-1 and cyclin B1 protein expression in patients with hypopharyngeal squamous cell carcinoma
by: LI, WUJIE, et al.
Published: (2016)

Endoscopic Resection of Hypopharyngeal Squamous Cell Carcinoma
by: Bok, Gene Hyun, et al.
Published: (2013)

Inhibition of PHLPP2/cyclin D1 protein translation contributes to the tumor suppressive effect of NFκB2 (p100)
by: Xu, Jiawei, et al.
Published: (2016)

Suppression in PHLPP2 induction by morin promotes Nrf2-regulated cellular defenses against oxidative injury to primary rat hepatocytes
by: Rizvi, Fatima, et al.
Published: (2015)

Mir-135a enhances cellular proliferation through post-transcriptionally regulating PHLPP2 and FOXO1 in human bladder cancer
by: Mao, Xiao Peng, et al.
Published: (2015)

Overexpression of miRNA 4451 is Associated With a Poor Survival of Patients With Hypopharyngeal Cancer After Surgery With Postoperative Radiotherapy
by: Xinbo Xu, et al.
Published: (2018-10-01)

Overexpression of HSPA2 is correlated with poor prognosis in esophageal squamous cell carcinoma
by: Zhang, Hang, et al.
Published: (2013)

Free posterior tibial flap reconstruction for hypopharyngeal squamous cell carcinoma
by: Chen, Fei, et al.
Published: (2014)

A case of peritoneal metastasis during treatment for hypopharyngeal squamous cell carcinoma
by: Wakasaki, Takahiro, et al.
Published: (2016)

Predictors of Thyroid Gland Involvement in Hypopharyngeal Squamous Cell Carcinoma
by: Chang, Jae Won, et al.
Published: (2015)

STK33 overexpression in hypopharyngeal squamous cell carcinoma: possible role in tumorigenesis
by: Huang, Lingyan, et al.
Published: (2015)

The Expression of SIRT1 and DBC1 in Laryngeal and Hypopharyngeal Carcinomas
by: Yu, Xue-Min, et al.
Published: (2013)

DEPTOR suppresses the progression of esophageal squamous cell carcinoma and predicts poor prognosis
by: Ji, Yan-Mei, et al.
Published: (2016)

Upregulation of MAGEA4 correlates with poor prognosis in patients with early stage of esophageal squamous cell carcinoma
by: Tang, Wei-Wei, et al.
Published: (2016)

Chloroquine-Enhanced Efficacy of Cisplatin in the Treatment of Hypopharyngeal Carcinoma in Xenograft Mice
by: Zhao, Xing-guo, et al.
Published: (2015)

High DEPTOR expression correlates with poor prognosis in patients with esophageal squamous cell carcinoma
by: Liu, Nan-bo, et al.
Published: (2015)

NFκB1 (p50) suppresses SOD2 expression by inhibiting FoxO3a transactivation in a miR190/PHLPP1/Akt-dependent axis
by: Du, Kejun, et al.
Published: (2013)

WD Repeat Protein WDR48 in Complex with Deubiquitinase USP12 Suppresses Akt-dependent Cell Survival Signaling by Stabilizing PH Domain Leucine-rich Repeat Protein Phosphatase 1 (PHLPP1)*
by: Gangula, Narmadha Reddy, et al.
Published: (2013)

Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) and PH Domain and Leucine-rich Repeat Phosphatase Cross-talk (PHLPP) in Cancer Cells and in Transforming Growth Factor β-Activated Stem Cells*
by: Ghalali, Aram, et al.
Published: (2014)

MiR-135a Protects Vascular Endothelial Cells Against Ventilator-Induced Lung Injury by Inhibiting PHLPP2 to Activate PI3K/Akt Pathway
by: Xiaodi Yan, et al.
Published: (2018-07-01)

The N-terminal region of p27 inhibits HIF-1α protein translation in ribosomal protein S6-dependent manner by regulating PHLPP-Ras-ERK-p90RSK axis
by: Zhang, D, et al.
Published: (2014)