White Matter Hyperintensities among Older Adults Are Associated with Futile Increase in Frontal Activation and Functional Connectivity during Spatial Search

The mechanisms by which aging and other processes can affect the structure and function of brain networks are important to understanding normal age-related cognitive decline. Advancing age is known to be associated with various disease processes, including clinically asymptomatic vascular and inflam...

Full description

Bibliographic Details
Main Authors: Lockhart, Samuel N., Luck, Steven J., Geng, Joy, Beckett, Laurel, Disbrow, Elizabeth A., Carmichael, Owen, DeCarli, Charles
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368687/