The Forgotten Role of Central Volume in Low Frequency Oscillations of Heart Rate Variability
The hypothesis that central volume plays a key role in the source of low frequency (LF) oscillations of heart rate variability (HRV) was tested in a population of end stage renal disease patients undergoing conventional hemodialysis (HD) treatment, and thus subject to large fluid shifts and sympathe...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Public Library of Science
2015
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368684/ |
| id |
pubmed-4368684 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-43686842015-03-27 The Forgotten Role of Central Volume in Low Frequency Oscillations of Heart Rate Variability Ferrario, Manuela Moissl, Ulrich Garzotto, Francesco Cruz, Dinna N. Tetta, Ciro Signorini, Maria G. Ronco, Claudio Grassmann, Aileen Cerutti, Sergio Guzzetti, Stefano Research Article The hypothesis that central volume plays a key role in the source of low frequency (LF) oscillations of heart rate variability (HRV) was tested in a population of end stage renal disease patients undergoing conventional hemodialysis (HD) treatment, and thus subject to large fluid shifts and sympathetic activation. Fluid overload (FO) in 58 chronic HD patients was assessed by whole body bioimpedance measurements before the midweek HD session. Heart Rate Variability (HRV) was measured using 24-hour Holter electrocardiogram recordings starting before the same HD treatment. Time domain and frequency domain analyses were performed on HRV signals. Patients were retrospectively classified in three groups according to tertiles of FO normalized to the extracellular water (FO/ECW%). These groups were also compared after stratification by diabetes mellitus. Patients with the low to medium hydration status before the treatment (i.e. 1st and 2nd FO/ECW% tertiles) showed a significant increase in LF power during last 30 min of HD compared to dialysis begin, while no significant change in LF power was seen in the third group (i.e. those with high pre-treatment hydration values). In conclusion, several mechanisms can generate LF oscillations in the cardiovascular system, including baroreflex feedback loops and central oscillators. However, the current results emphasize the role played by the central volume in determining the power of LF oscillations. Public Library of Science 2015-03-20 /pmc/articles/PMC4368684/ /pubmed/25793464 http://dx.doi.org/10.1371/journal.pone.0120167 Text en © 2015 Ferrario et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Ferrario, Manuela Moissl, Ulrich Garzotto, Francesco Cruz, Dinna N. Tetta, Ciro Signorini, Maria G. Ronco, Claudio Grassmann, Aileen Cerutti, Sergio Guzzetti, Stefano |
| spellingShingle |
Ferrario, Manuela Moissl, Ulrich Garzotto, Francesco Cruz, Dinna N. Tetta, Ciro Signorini, Maria G. Ronco, Claudio Grassmann, Aileen Cerutti, Sergio Guzzetti, Stefano The Forgotten Role of Central Volume in Low Frequency Oscillations of Heart Rate Variability |
| author_facet |
Ferrario, Manuela Moissl, Ulrich Garzotto, Francesco Cruz, Dinna N. Tetta, Ciro Signorini, Maria G. Ronco, Claudio Grassmann, Aileen Cerutti, Sergio Guzzetti, Stefano |
| author_sort |
Ferrario, Manuela |
| title |
The Forgotten Role of Central Volume in Low Frequency Oscillations of Heart Rate Variability |
| title_short |
The Forgotten Role of Central Volume in Low Frequency Oscillations of Heart Rate Variability |
| title_full |
The Forgotten Role of Central Volume in Low Frequency Oscillations of Heart Rate Variability |
| title_fullStr |
The Forgotten Role of Central Volume in Low Frequency Oscillations of Heart Rate Variability |
| title_full_unstemmed |
The Forgotten Role of Central Volume in Low Frequency Oscillations of Heart Rate Variability |
| title_sort |
forgotten role of central volume in low frequency oscillations of heart rate variability |
| description |
The hypothesis that central volume plays a key role in the source of low frequency (LF) oscillations of heart rate variability (HRV) was tested in a population of end stage renal disease patients undergoing conventional hemodialysis (HD) treatment, and thus subject to large fluid shifts and sympathetic activation. Fluid overload (FO) in 58 chronic HD patients was assessed by whole body bioimpedance measurements before the midweek HD session. Heart Rate Variability (HRV) was measured using 24-hour Holter electrocardiogram recordings starting before the same HD treatment. Time domain and frequency domain analyses were performed on HRV signals. Patients were retrospectively classified in three groups according to tertiles of FO normalized to the extracellular water (FO/ECW%). These groups were also compared after stratification by diabetes mellitus. Patients with the low to medium hydration status before the treatment (i.e. 1st and 2nd FO/ECW% tertiles) showed a significant increase in LF power during last 30 min of HD compared to dialysis begin, while no significant change in LF power was seen in the third group (i.e. those with high pre-treatment hydration values). In conclusion, several mechanisms can generate LF oscillations in the cardiovascular system, including baroreflex feedback loops and central oscillators. However, the current results emphasize the role played by the central volume in determining the power of LF oscillations. |
| publisher |
Public Library of Science |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368684/ |
| _version_ |
1613201787565637632 |