CD39 deficiency in murine liver allografts promotes inflammatory injury and immune-mediated rejection
Adenosine triphosphate (ATP), an essential metabolic energy source, is released following cell apoptosis or necrosis. It acts as a damage-associated molecule pattern to stimulate innate immune cells. The ectonucleotidase CD39 regulates immune activation by hydrolysis of extracellular ATP. We have sh...
| Main Authors: | , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368493/ |