Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer’s disease

Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer’s disease

The brains of Alzheimer’s disease (AD) patients are characterized by deposits of Abeta peptides and by accompanying chronic inflammation. Here, we provide evidence that the enzyme isoglutaminyl cyclase (isoQC) is a novel factor contributing to both aspects of AD pathology. Two putative substrates of...

Full description

Bibliographic Details
Main Authors:	Hartlage-Rübsamen, Maike, Waniek, Alexander, Meißner, Juliane, Morawski, Markus, Schilling, Stephan, Jäger, Carsten, Kleinschmidt, Martin, Cynis, Holger, Kehlen, Astrid, Arendt, Thomas, Demuth, Hans-Ulrich, Roßner, Steffen
Format:	Online
Language:	English
Published:	Springer Berlin Heidelberg 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366547/

Similar Items

Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms
by: Hartlage-Rübsamen, Maike, et al.
Published: (2011)

The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions
by: Cynis, Holger, et al.
Published: (2011)

Glutaminyl cyclase-mediated toxicity of pyroglutamate-beta amyloid induces striatal neurodegeneration
by: Becker, Andreas, et al.
Published: (2013)

Effect of brevican deficiency on neuroplasticity mediating molecules
by: Weigel, Solveig, et al.
Published: (2015)

CCL2 Disrupts the Adherens Junction: Implications for Neuroinflammation
by: Roberts, Toni K., et al.
Published: (2012)

Heteroarylketones inhibit astroglial interleukin-6 expression via a STAT3/NF-κB signaling pathway
by: Schulz, Ingo, et al.
Published: (2011)

Interfering with the CCL2–glycosaminoglycan axis as a potential approach to modulate neuroinflammation
by: Gschwandtner, Martha, et al.
Published: (2016)

Role of NO-sensitive guanylyl cyclase in angiogenesis and arteriogenesis
by: Bettaga, Noomen, et al.
Published: (2013)

Expression of Ccl11 Associates with Immune Response Modulation and Protection against Neuroinflammation in Rats
by: Adzemovic, Milena Z., et al.
Published: (2012)

Resolution of central nervous system astrocytic and endothelial sources of CCL2 gene expression during evolving neuroinflammation
by: Shrestha, Bandana, et al.
Published: (2014)

Nucleotidyl cyclase activity of recombinant soluble guanylyl cyclase
by: Rauch, Kerstin, et al.
Published: (2009)

The Correlation of Serums CCL11, CCL17, CCL26, and CCL27 and Disease Severity in Patients with Urticaria
by: Lu, Tao, et al.
Published: (2016)

Passive Immunization against Pyroglutamate-3 Amyloid-β Reduces Plaque Burden in Alzheimer-Like Transgenic Mice: A Pilot Study
by: Frost, Jeffrey L., et al.
Published: (2012)

Nucleotidyl Cyclase Activity of Particulate Guanylyl Cyclase A: Comparison with Particulate Guanylyl Cyclases E and F, Soluble Guanylyl Cyclase and Bacterial Adenylyl Cyclases Cyaa and Edema Factor
by: Beste, Kerstin Y., et al.
Published: (2013)

Mediators of Neuroinflammation
by: Ramesh, Geeta, et al.
Published: (2013)

Stimulation of MMP-1 and CCL2 by NAMPT in PDL Cells
by: Nokhbehsaim, Marjan, et al.
Published: (2013)

Natural Products from Microalgae with Potential against Alzheimer’s Disease: Sulfolipids Are Potent Glutaminyl Cyclase Inhibitors
by: Hielscher-Michael, Stephanie, et al.
Published: (2016)

Higher Expression of CCL2, CCL4, CCL5, CCL21, and CXCL8 Chemokines in the Skin Associated with Parasite Density in Canine Visceral Leishmaniasis
by: Menezes-Souza, Daniel, et al.
Published: (2012)

Ragweed-allergic subjects have decreased serum levels of chemokines CCL2, CCL3, CCL4 and CCL5 out of the pollen season
by: Kostova, Zhivka, et al.
Published: (2016)

Cell-selective knockout and 3D confocal image analysis reveals separate roles for astrocyte-and endothelial-derived CCL2 in neuroinflammation
by: Paul, Debayon, et al.
Published: (2014)

Biochemical Analysis of Matrix Metalloproteinase Activation of Chemokines CCL15 and CCL23 and Increased Glycosaminoglycan Binding of CCL16*
by: Starr, Amanda E., et al.
Published: (2012)

Conjoined NO-sensitive guanylyl cyclases
by: Behrends, Sönke, et al.
Published: (2011)

Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells
by: Pharoah, Daniel S, et al.
Published: (2006)

Reorganization of Synaptic Connections and Perineuronal Nets in the Deep Cerebellar Nuclei of Purkinje Cell Degeneration Mutant Mice
by: Blosa, M., et al.
Published: (2016)

Early neurone loss in Alzheimer’s disease: cortical or subcortical?
by: Arendt, Thomas, et al.
Published: (2015)

Evolution of CCL3L1/CCL4L1 haplotypes
by: Janyakhantikul, Somwang
Published: (2011)

Eosinophils in Colorectal Neoplasms Associated with Expression of CCL11 and CCL24
by: Cho, Hyuck, et al.
Published: (2016)

Differential Dermal Expression of CCL17 and CCL18 in Tuberculoid and Lepromatous Leprosy
by: Berrington, William R., et al.
Published: (2014)

CCL19 and CCL21 modulate the inflammatory milieu in atherosclerotic lesions
by: Akhavanpoor, Mohammadreza, et al.
Published: (2014)

Immunotherapy targeting pyroglutamate-3 Aβ: prospects and challenges
by: Cynis, Holger, et al.
Published: (2016)

Detecting neuroinflammation with molecular MRI
by: Yanez Lopez, Maria
Published: (2015)

Welcome to the Journal of Neuroinflammation!
by: Mrak, Robert E, et al.
Published: (2004)

PPARγ, neuroinflammation, and disease
by: Mrak, Robert E, et al.
Published: (2004)

Noninvasive molecular imaging of neuroinflammation
by: Jacobs, Andreas H, et al.
Published: (2012)

Neuroinflammation and psychiatric illness
by: Najjar, Souhel, et al.
Published: (2013)

Neuroinflammation and Copper in Alzheimer's Disease
by: Choo, Xin Yi, et al.
Published: (2013)

Neuroinflammation in autism spectrum disorders
by: El-Ansary, Afaf, et al.
Published: (2012)

Exosomes as mediators of neuroinflammation
by: Gupta, Archana, et al.
Published: (2014)

Innate Immunity and Neuroinflammation
by: Shastri, Abhishek, et al.
Published: (2013)

Targeting neuroinflammation in Alzheimer’s disease
by: Bronzuoli, Maria Rosanna, et al.
Published: (2016)