Developmental Changes in the Corpus Callosum from Infancy to Early Adulthood: A Structural Magnetic Resonance Imaging Study

Previous research has reported on the development trajectory of the corpus callosum morphology. However, there have been only a few studies that have included data on infants. The goal of the present study was to examine the morphology of the corpus callosum in healthy participants of both sexes, fr...

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Main Authors:	Tanaka-Arakawa, Megumi M., Matsui, Mie, Tanaka, Chiaki, Uematsu, Akiko, Uda, Satoshi, Miura, Kayoko, Sakai, Tomoko, Noguchi, Kyo
Format:	Online
Language:	English
Published:	Public Library of Science 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366394/

id	pubmed-4366394
recordtype	oai_dc
spelling	pubmed-43663942015-03-23 Developmental Changes in the Corpus Callosum from Infancy to Early Adulthood: A Structural Magnetic Resonance Imaging Study Tanaka-Arakawa, Megumi M. Matsui, Mie Tanaka, Chiaki Uematsu, Akiko Uda, Satoshi Miura, Kayoko Sakai, Tomoko Noguchi, Kyo Research Article Previous research has reported on the development trajectory of the corpus callosum morphology. However, there have been only a few studies that have included data on infants. The goal of the present study was to examine the morphology of the corpus callosum in healthy participants of both sexes, from infancy to early adulthood. We sought to characterize normal development of the corpus callosum and possible sex differences in development. We performed a morphometric magnetic resonance imaging (MRI) study of 114 healthy individuals, aged 1 month to 25 years old, measuring the size of the corpus callosum. The corpus callosum was segmented into seven subareas of the rostrum, genu, rostral body, anterior midbody, posterior midbody, isthmus and splenium. Locally weighted regression analysis (LOESS) indicated significant non-linear age-related changes regardless of sex, particularly during the first few years of life. After this increase, curve slopes gradually became flat during adolescence and adulthood in both sexes. Age of local maximum for each subarea of the corpus callosum differed across the sexes. Ratios of total corpus callosum and genu, posterior midbody, as well as splenium to the whole brain were significantly higher in females compared with males. The present results demonstrate that the developmental trajectory of the corpus callosum during early life in healthy individuals is non-linear and dynamic. This pattern resembles that found for the cerebral cortex, further suggesting that this period plays a very important role in neural and functional development. In addition, developmental trajectories and changes in growth do show some sex differences. Public Library of Science 2015-03-19 /pmc/articles/PMC4366394/ /pubmed/25790124 http://dx.doi.org/10.1371/journal.pone.0118760 Text en © 2015 Tanaka-Arakawa et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Tanaka-Arakawa, Megumi M. Matsui, Mie Tanaka, Chiaki Uematsu, Akiko Uda, Satoshi Miura, Kayoko Sakai, Tomoko Noguchi, Kyo
spellingShingle	Tanaka-Arakawa, Megumi M. Matsui, Mie Tanaka, Chiaki Uematsu, Akiko Uda, Satoshi Miura, Kayoko Sakai, Tomoko Noguchi, Kyo Developmental Changes in the Corpus Callosum from Infancy to Early Adulthood: A Structural Magnetic Resonance Imaging Study
author_facet	Tanaka-Arakawa, Megumi M. Matsui, Mie Tanaka, Chiaki Uematsu, Akiko Uda, Satoshi Miura, Kayoko Sakai, Tomoko Noguchi, Kyo
author_sort	Tanaka-Arakawa, Megumi M.
title	Developmental Changes in the Corpus Callosum from Infancy to Early Adulthood: A Structural Magnetic Resonance Imaging Study
title_short	Developmental Changes in the Corpus Callosum from Infancy to Early Adulthood: A Structural Magnetic Resonance Imaging Study
title_full	Developmental Changes in the Corpus Callosum from Infancy to Early Adulthood: A Structural Magnetic Resonance Imaging Study
title_fullStr	Developmental Changes in the Corpus Callosum from Infancy to Early Adulthood: A Structural Magnetic Resonance Imaging Study
title_full_unstemmed	Developmental Changes in the Corpus Callosum from Infancy to Early Adulthood: A Structural Magnetic Resonance Imaging Study
title_sort	developmental changes in the corpus callosum from infancy to early adulthood: a structural magnetic resonance imaging study
description	Previous research has reported on the development trajectory of the corpus callosum morphology. However, there have been only a few studies that have included data on infants. The goal of the present study was to examine the morphology of the corpus callosum in healthy participants of both sexes, from infancy to early adulthood. We sought to characterize normal development of the corpus callosum and possible sex differences in development. We performed a morphometric magnetic resonance imaging (MRI) study of 114 healthy individuals, aged 1 month to 25 years old, measuring the size of the corpus callosum. The corpus callosum was segmented into seven subareas of the rostrum, genu, rostral body, anterior midbody, posterior midbody, isthmus and splenium. Locally weighted regression analysis (LOESS) indicated significant non-linear age-related changes regardless of sex, particularly during the first few years of life. After this increase, curve slopes gradually became flat during adolescence and adulthood in both sexes. Age of local maximum for each subarea of the corpus callosum differed across the sexes. Ratios of total corpus callosum and genu, posterior midbody, as well as splenium to the whole brain were significantly higher in females compared with males. The present results demonstrate that the developmental trajectory of the corpus callosum during early life in healthy individuals is non-linear and dynamic. This pattern resembles that found for the cerebral cortex, further suggesting that this period plays a very important role in neural and functional development. In addition, developmental trajectories and changes in growth do show some sex differences.
publisher	Public Library of Science
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366394/
_version_	1613201017281708032

Developmental Changes in the Corpus Callosum from Infancy to Early Adulthood: A Structural Magnetic Resonance Imaging Study

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