Vitamin D binding protein genotype is associated with plasma 25OHD concentration in West African children
Vitamin D is well known for its role in promoting skeletal health. Vitamin D status is determined conventionally by circulating 25-dihydroxyvitamin D (25OHD) concentration. There is evidence indicating that circulating 25OHD concentration is affected by variation in Gc, the gene encoding the vitamin...
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| Format: | Online |
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Elsevier Science
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366041/ |
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pubmed-43660412015-05-01 Vitamin D binding protein genotype is associated with plasma 25OHD concentration in West African children Braithwaite, V.S. Jones, K.S. Schoenmakers, I. Silver, M. Prentice, A. Hennig, B.J. Rapid Communication Vitamin D is well known for its role in promoting skeletal health. Vitamin D status is determined conventionally by circulating 25-dihydroxyvitamin D (25OHD) concentration. There is evidence indicating that circulating 25OHD concentration is affected by variation in Gc, the gene encoding the vitamin D binding protein (DBP). The composite genotype of two single nucleotide polymorphisms (rs7041 and rs4588) results in different DBP isotypes (Gc1f, Gc1s and Gc2). The protein configurational differences among DBP isotypes affect DBP substrate binding affinity. Elsevier Science 2015-05 /pmc/articles/PMC4366041/ /pubmed/25652210 http://dx.doi.org/10.1016/j.bone.2014.12.068 Text en © 2015 The Authors. Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Braithwaite, V.S. Jones, K.S. Schoenmakers, I. Silver, M. Prentice, A. Hennig, B.J. |
| spellingShingle |
Braithwaite, V.S. Jones, K.S. Schoenmakers, I. Silver, M. Prentice, A. Hennig, B.J. Vitamin D binding protein genotype is associated with plasma 25OHD concentration in West African children |
| author_facet |
Braithwaite, V.S. Jones, K.S. Schoenmakers, I. Silver, M. Prentice, A. Hennig, B.J. |
| author_sort |
Braithwaite, V.S. |
| title |
Vitamin D binding protein genotype is associated with plasma 25OHD concentration in West African children |
| title_short |
Vitamin D binding protein genotype is associated with plasma 25OHD concentration in West African children |
| title_full |
Vitamin D binding protein genotype is associated with plasma 25OHD concentration in West African children |
| title_fullStr |
Vitamin D binding protein genotype is associated with plasma 25OHD concentration in West African children |
| title_full_unstemmed |
Vitamin D binding protein genotype is associated with plasma 25OHD concentration in West African children |
| title_sort |
vitamin d binding protein genotype is associated with plasma 25ohd concentration in west african children |
| description |
Vitamin D is well known for its role in promoting skeletal health. Vitamin D status is determined conventionally by circulating 25-dihydroxyvitamin D (25OHD) concentration. There is evidence indicating that circulating 25OHD concentration is affected by variation in Gc, the gene encoding the vitamin D binding protein (DBP). The composite genotype of two single nucleotide polymorphisms (rs7041 and rs4588) results in different DBP isotypes (Gc1f, Gc1s and Gc2). The protein configurational differences among DBP isotypes affect DBP substrate binding affinity. |
| publisher |
Elsevier Science |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366041/ |
| _version_ |
1613200871316783104 |