A PAX1 enhancer locus is associated with susceptibility to idiopathic scoliosis in females

A PAX1 enhancer locus is associated with susceptibility to idiopathic scoliosis in females

Idiopathic scoliosis (IS) is a common paediatric musculoskeletal disease that displays a strong female bias. By performing a genome-wide association study (GWAS) of 3,102 individuals, we identify significant associations with 20p11.22 SNPs for females (P=6.89 × 10−9) but not males (P=0.71). This ass...

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Bibliographic Details
Main Authors: Sharma, Swarkar, Londono, Douglas, Eckalbar, Walter L., Gao, Xiaochong, Zhang, Dongping, Mauldin, Kristen, Kou, Ikuyo, Takahashi, Atsushi, Matsumoto, Morio, Kamiya, Nobuhiro, Murphy, Karl K., Cornelia, Reuel, Herring, John A., Burns, Dennis, Ahituv, Nadav, Ikegawa, Shiro, Gordon, Derek, Wise, Carol A.
Format: Online
Language:English
Published: Nature Pub. Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365504/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365504/

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