Dystrophic Spinal Deformities in a Neurofibromatosis Type 1 Murine Model

Dystrophic Spinal Deformities in a Neurofibromatosis Type 1 Murine Model

Despite the high prevalence and significant morbidity of spinal anomalies in neurofibromatosis type 1 (NF1), the pathogenesis of these defects remains largely unknown. Here, we present two murine models: Nf1flox/−;PeriCre and Nf1flox/−;Col.2.3Cre mice, which recapitulate spinal deformities seen in t...

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Bibliographic Details
Main Authors: Rhodes, Steven D., Zhang, Wei, Yang, Dalong, Yang, Hao, Chen, Shi, Wu, Xiaohua, Li, Xiaohong, Yang, Xianlin, Mohammad, Khalid S., Guise, Theresa A., Bergner, Amanda L., Stevenson, David A., Yang, Feng-Chun
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364663/

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