Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA
Cytosine residues in mammalian DNA occur in five forms, cytosine (C), 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). The ten-eleven translocation (Tet) dioxygenases convert 5mC to 5hmC, 5fC and 5caC in three consecutive, Fe(II)- and α-ke...
| Main Authors: | , , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364404/ |