Polymorphisms of Chicken TLR3 and 7 in Different Breeds

Toll-like receptors (TLRs) mediate immune responses via the recognition of pathogen-associated molecular patterns (PAMPs), thus playing important roles in host defense. Among the chicken (Ch) TLR family, ChTLR3 and 7 have been shown to recognize viral RNA. In our earlier studies, we have reported po...

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Main Authors:	Ruan, Wenke, An, Jian, Wu, Yanhua
Format:	Online
Language:	English
Published:	Public Library of Science 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364021/

id	pubmed-4364021
recordtype	oai_dc
spelling	pubmed-43640212015-03-23 Polymorphisms of Chicken TLR3 and 7 in Different Breeds Ruan, Wenke An, Jian Wu, Yanhua Research Article Toll-like receptors (TLRs) mediate immune responses via the recognition of pathogen-associated molecular patterns (PAMPs), thus playing important roles in host defense. Among the chicken (Ch) TLR family, ChTLR3 and 7 have been shown to recognize viral RNA. In our earlier studies, we have reported polymorphisms of TLR1, 2, 4, 5, 15 and 21. In the present study, we amplified TLR3 and 7 genes from different chicken breeds and analyzed their sequences. We identified 7 amino acid polymorphism sites in ChTLR3 with 6 outer part sites and 1 inner part site, and 4 amino acid polymorphism sites in ChTLR7 with 3 outer part sites and 1 inner part site. These results demonstrate that ChTLR genes are polymorphic among different chicken breeds, suggesting a varied resistance across numerous chicken breeds. This information might help improve chicken health by breeding and vaccination. Public Library of Science 2015-03-17 /pmc/articles/PMC4364021/ /pubmed/25781886 http://dx.doi.org/10.1371/journal.pone.0119967 Text en © 2015 Ruan et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Ruan, Wenke An, Jian Wu, Yanhua
spellingShingle	Ruan, Wenke An, Jian Wu, Yanhua Polymorphisms of Chicken TLR3 and 7 in Different Breeds
author_facet	Ruan, Wenke An, Jian Wu, Yanhua
author_sort	Ruan, Wenke
title	Polymorphisms of Chicken TLR3 and 7 in Different Breeds
title_short	Polymorphisms of Chicken TLR3 and 7 in Different Breeds
title_full	Polymorphisms of Chicken TLR3 and 7 in Different Breeds
title_fullStr	Polymorphisms of Chicken TLR3 and 7 in Different Breeds
title_full_unstemmed	Polymorphisms of Chicken TLR3 and 7 in Different Breeds
title_sort	polymorphisms of chicken tlr3 and 7 in different breeds
description	Toll-like receptors (TLRs) mediate immune responses via the recognition of pathogen-associated molecular patterns (PAMPs), thus playing important roles in host defense. Among the chicken (Ch) TLR family, ChTLR3 and 7 have been shown to recognize viral RNA. In our earlier studies, we have reported polymorphisms of TLR1, 2, 4, 5, 15 and 21. In the present study, we amplified TLR3 and 7 genes from different chicken breeds and analyzed their sequences. We identified 7 amino acid polymorphism sites in ChTLR3 with 6 outer part sites and 1 inner part site, and 4 amino acid polymorphism sites in ChTLR7 with 3 outer part sites and 1 inner part site. These results demonstrate that ChTLR genes are polymorphic among different chicken breeds, suggesting a varied resistance across numerous chicken breeds. This information might help improve chicken health by breeding and vaccination.
publisher	Public Library of Science
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364021/
_version_	1613200121371033600

Polymorphisms of Chicken TLR3 and 7 in Different Breeds

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