High Frequency of Transmitted HIV-1 Gag HLA Class I-Driven Immune Escape Variants but Minimal Immune Selection over the First Year of Clade C Infection

High Frequency of Transmitted HIV-1 Gag HLA Class I-Driven Immune Escape Variants but Minimal Immune Selection over the First Year of Clade C Infection

In chronic HIV infection, CD8+ T cell responses to Gag are associated with lower viral loads, but longitudinal studies of HLA-restricted CD8+ T cell-driven selection pressure in Gag from the time of acute infection are limited. In this study we examined Gag sequence evolution over the first year of...

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Bibliographic Details
Main Authors: Gounder, Kamini, Padayachi, Nagavelli, Mann, Jaclyn K., Radebe, Mopo, Mokgoro, Mammekwa, van der Stok, Mary, Mkhize, Lungile, Mncube, Zenele, Jaggernath, Manjeetha, Reddy, Tarylee, Walker, Bruce D., Ndung’u, Thumbi
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363590/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363590/

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