DISC1 regulates trafficking and processing of APP and Aβ generation

DISC1 regulates trafficking and processing of APP and Aβ generation

We report the novel regulation of proteolytic processing of amyloid precursor protein (APP) by DISC1, a major risk factor for psychiatric illnesses, such as depression and schizophrenia. RNAi-knockdown of DISC1 in mature primary cortical neurons led to a significant increase in the levels of intrace...

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Bibliographic Details
Main Authors: Shahani, Neelam, Seshadri, Saurav, Jaaro-Peled, Hanna, Ishizuka, Koko, Hirota-Tsuyada, Yuki, Wang, Qi, Koga, Minori, Sedlak, Thomas W., Korth, Carsten, Brandon, Nicholas J., Kamiya, Atsushi, Subramaniam, Srinivasa, Tomoda, Toshifumi, Sawa, Akira
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362789/

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