Suppression of leaky expression of adenovirus genes by insertion of microRNA-targeted sequences in the replication-incompetent adenovirus vector genome

Suppression of leaky expression of adenovirus genes by insertion of microRNA-targeted sequences in the replication-incompetent adenovirus vector genome

Leaky expression of adenovirus (Ad) genes occurs following transduction with a conventional replication-incompetent Ad vector, leading to an induction of cellular immunity against Ad proteins and Ad protein-induced toxicity, especially in the late phase following administration. To suppress the leak...

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Bibliographic Details
Main Authors: Shimizu, Kahori, Sakurai, Fuminori, Tomita, Kyoko, Nagamoto, Yasuhito, Nakamura, Shin-ichiro, Katayama, Kazufumi, Tachibana, Masashi, Kawabata, Kenji, Mizuguchi, Hiroyuki
Format: Online
Language:English
Published: Nature Publishing Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362365/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362365/

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