PhyloWGS: Reconstructing subclonal composition and evolution from whole-genome sequencing of tumors
Tumors often contain multiple subpopulations of cancerous cells defined by distinct somatic mutations. We describe a new method, PhyloWGS, which can be applied to whole-genome sequencing data from one or more tumor samples to reconstruct complete genotypes of these subpopulations based on variant al...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
BioMed Central
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359439/ |